Association of aldosterone synthase polymorphism (CYP11B2 -344T>C) and genetic ancestry with atrial fibrillation and serum aldosterone in African Americans with heart failure.

TitleAssociation of aldosterone synthase polymorphism (CYP11B2 -344T>C) and genetic ancestry with atrial fibrillation and serum aldosterone in African Americans with heart failure.
Publication TypeJournal Article
Year of Publication2013
AuthorsBress A, Han J, Patel SR, Desai AA, Mansour I, Groo V, Progar K, Shah E, Stamos TD, Wing C, Garcia JGN, Kittles R, Cavallari LH
JournalPLoS One
Volume8
Issue7
Paginatione71268
Date Published2013
ISSN Number1932-6203
KeywordsAdult, African Americans, Aged, Aldosterone, Alleles, Atrial Fibrillation, Cytochrome P-450 CYP11B2, European Continental Ancestry Group, Female, Gene Frequency, Genetic Association Studies, Genotype, Heart Failure, Humans, Male, Middle Aged, Polymorphism, Genetic, Risk Factors
Abstract

<p>The objective of this study was to examine the extent to which aldosterone synthase genotype (CYP11B2) and genetic ancestry correlate with atrial fibrillation (AF) and serum aldosterone in African Americans with heart failure. Clinical data, echocardiographic measurements, and a genetic sample for determination of CYP11B2 -344T>C (rs1799998) genotype and genetic ancestry were collected from 194 self-reported African Americans with chronic, ambulatory heart failure. Genetic ancestry was determined using 105 autosomal ancestry informative markers. In a sub-set of patients (n = 126), serum was also collected for determination of circulating aldosterone. The CYP11B2 -344C allele frequency was 18% among the study population, and 19% of patients had AF. Multiple logistic regression revealed that the CYP11B2 -344CC genotype was a significant independent predictor of AF (OR 12.7, 95% CI 1.60-98.4, p = 0.0150, empirical p = 0.011) while holding multiple clinical factors, left atrial size, and percent European ancestry constant. Serum aldosterone was significantly higher among patients with AF (p = 0.036), whereas increased West African ancestry was inversely correlated with serum aldosterone (r = -0.19, p = 0.037). The CYP11B2 -344CC genotype was also overrepresented among patients with extreme aldosterone elevation (≥90th percentile, p = 0.0145). In this cohort of African Americans with chronic ambulatory heart failure, the CYP11B2 -344T>C genotype was a significant independent predictor of AF while holding clinical, echocardiographic predictors, and genetic ancestry constant. In addition, increased West African ancestry was associated with decreased serum aldosterone levels, potentially providing an explanation for the lower risk for AF observed among African Americans.</p>

DOI10.1371/journal.pone.0071268
Alternate JournalPLoS ONE
PubMed ID23936266
PubMed Central IDPMC3728110
Grant ListAG033381-01 / AG / NIA NIH HHS / United States
UL1RR029879 / RR / NCRR NIH HHS / United States