Jason X.-J. Yuan, MD/PhD

Professor of Medicine and Physiology
Chief, Division of Translational and Regenerative Medicine
Department of Medicine
Associate Vice President for Translational Health Sciences
University of Arizona
Phone: 
(520) 621-0787
Location: 
Drachman Hall 2301 (Office)

Research Interests:

We are a research lab focused on vascular biology, electrophysiology, and the pathogenic mechanisms of pulmonary vascular disease. We use the combined techniques of patch clamping, digital imaging fluorescence microscopy, and cellular and molecular biology techniques to investigate the roles of membrane receptors, ion channels and intracellular Ca2+ signaling in regulating vasomotor tone, and pulmonary vascular smooth muscle proliferation and apoptosis in order to understand the molecular mechanisms of idiopathic and thromboembolic pulmonary hypertension. The aim of our investigation is to identify new therapeutic targets and treatment strategies for pulmonary hypertension.

 

Select Recent Publications (since 2012):

1.  Ogawa, A., A.L. Firth, K.A. Smith, M.V. Maliakal, and J.X.-J. Yuan. PDGF enhances store-operated Ca2+ entry by upregulating STIM1/Orai1 via activation of Akt/mTOR in human pulmonary arterial smooth muscle cells. Am. J. Physiol. Cell Physiol. 302:C405-C411, 2012.

2.  Makino, A. H. Wang, B.T. Scott, J.X.-J. Yuan, and W.H. Dillmann. Tyroid hormone receptor α and vascular function. Am. J. Physiol. Cell Physiol. 302(9):C1346-C1352, 2012.

3.  Zhao, Y.D., L. Cai, M.K. Mirza, X. Huang, D.L. Geenen, F. Hofmann, J.X.-J. Yuan, and Y.-Y. Zhao. Protein kinase G-I deficiency induces pulmonary hypertension through Rho A/Rho kinase activation. Am. J. Pathol. 180(6):2268-2275, 2012.

4.  Yamamura, A., Q. Guo, H. Yamamura, A.M. Zimnicka, N.M. Pohl, K.A. Smith, R.A. Fernandez, A. Zeifman, A. Makino, H. Dong, and J.X.-J. Yuan. Enhanced Ca2+-sensing receptor function in pulmonary arterial hypertension. Circ. Res. 111:469-481, 2012.

5.  Desai, A.A., T. Zhou, H. Ahmad, W. Zhang, W. Mu, S. Trevino, M.S. Wade, N. Raghavachari, G.J. Kato, M.H. Peters-Lawrence, T. Thiruvoipati, K. Turner, N. Artz, Y. Huang, A.R. Patel, J.X.-J. Yuan, V.R. Gordeuk, R.M. Lang, J.G.N. Garcia, and R.F. Machado. A novel molecular signature for elevated tricuspid regurgitation velocity in sickle cell disease. Am. J. Respir. Crit. Care Med. 186(4):359-368, 2012.

6.  Estrada, I.A., R. Donthamsetty, P. Debski, M.-H. Zhou, S.L. Zhang, J.X.-J. Yuan, W. Han, and A. Makino. STIM1 restores coronary endothelial function in type1 diabetic mice. Circ. Res. 111(9):1166-1175, 2012.

7.  Yoo, H.Y., A. Zeifman, E.A. Ko, K.A. Smith, J. Chen, R.F. Machado, Y.-Y. Zhao, R.D. Minshall, and J.X.-J. Yuan. Optimization of isolated perfused/ventilated mouse lung to study hypoxic pulmonary vasoconstriction. Pulm. Circ. 3(2):396-405, 2013.

8.  Yamamura, A., H. Yamamura, Q. Guo, A.M. Zimnicka, J. Wan, E.A. Ko, K.A. Smith, N.M. Pohl, S. Song, A. Zeifman, A. Makino, and J.X.-J. Yuan. Dihydropyridine Ca2+ channel blockers increase cytosolic [Ca2+] by activating Ca2+-sensing receptors in pulmonary arterial smooth muscle cells. Circ. Res. 112(4):640-650, 2013.

9.  Ko, E.A., J. Wan, A. Yamamura, A.M. Zimnicka, H. Yamamura, H.Y. Yoo, H. Tang, K.A. Smith, P.C. Sundivakkam, A. Zeifman, R.J. Ayon, A. Makino, and J.X.-J. Yuan. Functional characterization of voltage-dependent Ca2+ channels in mouse pulmonary artery smooth muscle cells: Divergent effect of ROS. Am. J. Physiol. Cell Physiol. 304(11):1042-1052, 2013.

10.  Wan, J., A. Yamamura, A. M. Zimnicka, G. Voiriot, K.A. Smith, H. Tang, R.J. Ayon, M.S.R. Choudhury, E.A. Ko, J. Wang, C. Wang, A. Makino, and J.X.-J. Yuan. Chronic hypoxia selectively enhances L- and T-type voltage-dependent Ca2+ channel activity in mouse pulmonary artery by upregulating Cav1.2 and Cav3.2. Am. J. Physiol. Lung Cell Mol Physiol. 305(2):L154-L164, 2013.

11.  Chen, J., G. Feng, Q. Guo, J.B. Wardenburg, S. Lin, I. Inoshima, R.Deaton, J.X.-J. Yuan, J.G.N. Garcia, R.F. Machado, M. Otto, and R.G. Wunderink. Transcriptional events during the recovery from MRSA lung infection: A mouse pneumonia model. PLoS One. 8(8):e70176. doi: 10.1371/journal.pone.0070176, 2013.

12.  Zimnicka, A.M., H. Tang, Q Guo, F.K. Kuhr, M.-J. Oh, J. Wan, J. Chen, K.A. Smith, D.R. Fraidenburg, M.S.R. Choudhry, I. Levitan, R.F. Machado, J.H. Kaplan, and J.X.-J. Yuan. Upregulated copper transporters in hypoxia-induced pulmonary hypertension. PLoS One. 9(3): e90544. doi:10.1371/journal.pone.0090544, 2014.

13.  Yamamura, H., A. Yamamura, E.A. Ko, N.M. Pohl, K.A. Smith, F.L. Powell, P.A. Thistlethwaite, and J.X.-J. Yuan. Activation of Notch signaling by short-term treatment with Jagged-1 enhances store-operated Ca2+ entry in human pulmonary artery smooth muscle cells. Am. J. Physiol. Cell Physiol. 306(9):C871-878, 2014.

14.  Song, S, A. Yamamura, H. Yamamura, R.J. Ayon, K.A. Smith, H. Tang, A. Makino, and J.X.-J. Yuan. Flow shear stress enhances intracellular Ca2+ signaling in pulmonary artery smooth muscle cells from patients with pulmonary arterial hypertension. Am. J. Physiol. Cell Physiol. 307(4):C373-C383, 2014.14.

 

Websites:
Division of Translational and Regenerative Medicine:  http://deptmedicine.arizona.edu/dtrm
Yuan Lab:  http://yuanlab.ahsc.arizona.edu