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Jeffrey R. Jacobson, MD
Education and Training:
1992 BS Mathematics, Massachusetts Institute of Technology, Cambridge MA
1996 MD New York University, New York, NY
1996-1997 Internship Internal Medicine, NYU/Bellevue Hospital, New York, NY
1997-1999 Residency Internal Medicine, NYU/Bellevue Hospital, New York, NY
2000-2004 Fellowship Pulmonary & Critical Care, John Hopkins University, Baltimore, MD
Clinical Research and Interests:
Dr. Jacobson’s research focuses on lung vascular diseases. His lab studies the cellular mechanisms involved in these diseases and employs relevant animal models of acute lung injury and radiation-induced lung injury to identify and evaluate novel therapeutic strategies. He is also interested in identifying genetic predispositions to acute lung injury in ICU patients and the management of patients with interstitial lung diseases.
Ma SF, Xie L, Pino-Yanes M, Sammani S, Wade MS, Letsiou E, Siegler J, Wang T, Infusino G, Kittles RA, Flores C, Zhou T, Prabhakar BS, Moreno-Vinasco L, Villar J, Jacobson JR, Dudek SM, Garcia JG. Type 2 Deiodase and host responses of sepsis in acute lung injury. Am J Respir Cell Mol Biol, 45(6):1203-11, 2011. PMID 21685153.
Mathew B*, Jacobson JR*, Berdyshev, Huang Y, Sun X, Zhao Y, Gerhold LM, Siegler J, Evenoski C, Wang T, Zhou T, Zaidi R, Moreno-Vinasco L, Bittman R, Chen CT, Lariviere PJ, Sammani S, Lussier YA, Dudek SM, Natarajan V, Weichselbaum RR, Garcia JG. Role of sphigolipids in murine radiation-induced lung injury: protection by sphingosine 1-phosphate analogs. FASEB J, 25(10):3388-400, 2011. PMID 21712494. (*co-first authors)
Mitra S, Sammani S, Wang T, Boone DL, Meyer NJ, Dudek SM, Moreno-Vinasco L, Garcia JG, Jacobson JR. Role of GADD45a in Akt phosphorylation and ubiquitination following mechanical stress-induced vascular injury. Am J Resp Crit Care Med, 184(9):1030-1040, 2011. PMID 21816939.
Infusino GA, Jacobson JR. Endohtelial FAK as a therapeutic target in disease. Microvasc Res, 83(1):89-96, 2012. PMID 22008516.
Menkontso Dessap A, Voiriot G, Zhou T, Marcos E, Dudek SM, Jacobson JR, Machado R, Adnot S, Brochard L, Maitre B, Garcia JG. Conflicting physiological and genomic cardiopulmonary effects of recruitment maneuvers in murine acute lung injury. Am J Respir Cell Mol Biol, 46(4):541-50, 2012. PMID 22135358.
Gorshkova I, Zhour T, Mathew B, Jacobson JR, Takekoshi D, Bhattacharya P, Smith B, Aydogan B, Weichselbaum RR, Natarajan V, Garcia JG, Berdyshev EV. Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression. J Lipid Res, 53(8):1553-68, 2012. PMID 22615416.
Chen W, Sammani S, Mitra S, Ma SF, Garica JG, Jacobson JR. Critical role for integrin β4 in the attenuation of murine acute lung injury by simvastatin. Am J Physiol Lung Cell Mol Physiol, 303(4): L279-285, 2012. PMID 22683568.
Sun X, Singleton PA, Letsiou E, Zhao J, Belvitch P, Sammani S, Chiang ET, Moreno-Vinasco L, Wade MS, Zhou T, Liu B, Parastatidas I, Thomson L, Ischiropoulous H, Natarajan V, Jacobson JR, Machado RF, Dudek SM, Garcia JG. Sphingosine 1-phsophate receptor 3 is a novel biomarker in acute lung injury. Am J Respir Cell Mol Biol, Jul 5, 2012 (epub ahead of print). PMID 22771388.
Singla S, Jacobson JR. Statins as a novel therapeutic strategy in acute lung injury. Pulm Circ, 2(4): 297-406, 2013. PMID 23372924.
Ephstein Y, Singleton P, Chen W, Wang L, Slagia R, Kanteti P, Dudek SM, Garia JGN, Jacobson JR. Critical role for S1PR1 and integrin β4 in HGF/c-Met-mediated increases in vascular integrity. J Biol Chem, 288(4): 2191-200, 2013. PMID 23212923.
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