Bime, C; Pouladi, N; Sammani, S; Batai, K; Casanova, N; Zhou, T; Kempf, CL; Sun, X; Camp, SM; Wang, T; Kittles, RA; Lussier, YA; Jones, TK; Reilly, JP; Meyer, NJ; Christie, JD; Karnes, J; Gonzalez-Garay, M; Christiani, DC; Yates, CR; Wurfel, MM; Meduri, GU; Garcia, JGN Genome Wide Association Study in African Americans with Acute Respiratory Distress Syndrome Identifies the Selectin P Ligand Gene as a Risk Factor. Am J Respir Crit Care Med, . 2018.
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Oita, RC; Camp, SM; Ma, W; Ceco, E; Harbeck, M; Singleton, P; Messana, J; Sun, X; Wang, T; Garcia, JGN Novel Mechanism for Nicotinamide Phosphoribosyltransferase Inhibition of TNF-α-Mediated Apoptosis in Human Lung Endothelial Cells. Am J Respir Cell Mol Biol, . 2018.
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Rosas, IO; Goldberg, HJ; Collard, HR; El-Chemaly, S; Flaherty, K; Hunninghake, GM; Lasky, JA; Lederer, DJ; Machado, R; Martinez, FJ; Maurer, R; Teller, D; Noth, I; Peters, E; Raghu, G; Garcia, JGN; Choi, AMK A Phase II Clinical Trial of Low-Dose Inhaled Carbon Monoxide in Idiopathic Pulmonary Fibrosis. Chest, 153(1), 94-104. 2018.
PMID: 29100885
Wang, X; Wang, L; Garcia, JGN; Dudek, SM; Shekhawat, GS; Dravid, VP The Significant Role of c-Abl Kinase in Barrier Altering Agonists-mediated Cytoskeletal Biomechanics. Sci Rep, 8(1), 1002. 2018.
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PMCID: PMC5772358.
Whitaker, ME; Nair, V; Sinari, S; Dherange, P; Natarajan, B; Trutter, L; Brittain, EL; Hemnes, AR; Austin, E; Patel, K; Black, SM; Garcia, JGN; Yuan, JX; Vanderpool, R; Rischard, F; Makino, A; Bedrick, EJ; Desai, AA Diabetes Mellitus Associates with Increased Right Ventricular Afterload and Remodeling in Pulmonary Arterial Hypertension. Am J Med, . 2018.
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Gross, CM; Kellner, M; Wang, T; Lu, Q; Sun, X; Zemskov, EA; Noonepalle, S; Kangath, A; Kumar, S; Gonzalez-Garay, M; Desai, AA; Aggarwal, S; Gorshkov, B; Klinger, C; Verin, AD; Catravas, JD; Jacobson, JR; Yuan, JXJ; Rafikov, R; Garcia, JGN; Black, SM LPS Induced Acute Lung Injury Involves the NF-κB-mediated Downregulation of SOX18. Am J Respir Cell Mol Biol, . 2017.
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Kumar, S; Sun, X; Noonepalle, SKumar; Lu, Q; Zemskov, E; Wang, T; Aggarwal, S; Gross, C; Sharma, S; Desai, AA; Hou, Y; Dasarathy, S; Qu, N; Reddy, V; Lee, SGon; Cherian-Shaw, M; Yuan, JXJ; Catravas, JD; Rafikov, R; Garcia, JGN; Black, SM Hyper-activation of pp60Src limits nitric oxide signaling by increasing asymmetric dimethylarginine levels during acute lung injury. Free Radic Biol Med, 102 217-228. 2017.
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Mascarenhas, JB; Tchourbanov, AY; Fan, H; Danilov, SM; Wang, T; Garcia, JGN Mechanical Stress and Single Nucleotide Variants Regulate Alternative Splicing of the MYLK Gene. Am J Respir Cell Mol Biol, 56(1), 29-37. 2017.
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Mascarenhas, JB; Tchourbanov, AY; Danilov, SM; Zhou, T; Wang, T; Garcia, JGN The Splicing Factor hnRNPA1 Regulates Alternate Splicing of the MYLK Gene. Am J Respir Cell Mol Biol, . 2017.
PMID: 29077485.
Palumbo, S; Shin, YJ; Ahmad, K; Desai, AA; Quijada, H; Mohamed, M; Knox, A; Sammani, S; Colson, BA; Wang, T; Garcia, JGN; Hecker, L Dysregulated Nox4 ubiquitination contributes to redox imbalance and age-related severity of acute lung injury. Am J Physiol Lung Cell Mol Physiol, 312(3), L297-L308. 2017.
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Szilágyi, KL; Liu, C; Zhang, X; Wang, T; Fortman, JD; Zhang, W; Garcia, JGN Epigenetic contribution of the myosin light chain kinase gene to the risk for acute respiratory distress syndrome. Transl Res, 180 12-21. 2017.
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Song, S; Ayon, RJ; Yamamura, A; Yamamura, H; Dash, S; Babicheva, A; Tang, H; Sun, X; Cordery, AG; Khalpey, Z; Black, SM; Desai, AA; Rischard, F; McDermott, KM; Garcia, JGN; Makino, A; Yuan, JXJ Capsaicin-induced Ca2+ signaling is enhanced via upregulated TRPV1 channels in pulmonary artery smooth muscle cells from patients with idiopathic PAH. Am J Physiol Lung Cell Mol Physiol, 312(3), L309-L325. 2017.
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Wang, T; Gross, C; Desai, AA; Zemskov, E; Wu, X; Garcia, AN; Jacobson, JR; Yuan, JXJ; Garcia, JGN; Black, SM Endothelial cell signaling and ventilator-induced lung injury: molecular mechanisms, genomic analyses, and therapeutic targets. Am J Physiol Lung Cell Mol Physiol, 312(4), L452-L476. 2017.
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Barreto-Luis, A; Pino-Yanes, M; Corrales, A; Campo, P; Callero, A; Acosta-Herrera, M; Cumplido, J; Ma, SF; Martinez-Tadeo, J; Villar, J; Garcia, JGN; Carrillo, T; Carracedo, Á; Blanca, M; Flores, C Genome-wide association study in Spanish identifies ADAM metallopeptidase with thrombospondin type 1 motif, 9 (ADAMTS9), as a novel asthma susceptibility gene. J Allergy Clin Immunol, 137(3), 964-6. 2016.
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Bime, C; Poongkunran, C; Borgstrom, M; Natt, B; Desai, H; Parthasarathy, S; Garcia, JGN Racial Differences in Mortality from Severe Acute Respiratory Failure in the United States, 2008-2012. Ann Am Thorac Soc, 13(12), 2184-2189. 2016.
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Bime, C; Zhou, T; Wang, T; Slepian, MJ; Garcia, JGN; Hecker, L Reactive oxygen species-associated molecular signature predicts survival in patients with sepsis. Pulm Circ, 6(2), 196-201. 2016.
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Danilov, SM; Lünsdorf, H; Akinbi, HT; Nesterovitch, AB; Epshtein, Y; Letsiou, E; Kryukova, OV; Piegeler, T; Golukhova, EZ; Schwartz, DE; Dull, RO; Minshall, RD; Kost, OA; Garcia, JGN Lysozyme and bilirubin bind to ACE and regulate its conformation and shedding. Sci Rep, 6 34913. 2016.
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de la Vega, MRojo; Dodson, M; Gross, C; Manzour, H; Lantz, C; Chapman, E; Wang, T; Black, SM; Garcia, JGN; Zhang, DD Role of Nrf2 and Autophagy in Acute Lung Injury. Curr Pharmacol Rep, 2(2), 91-101. 2016.
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Duarte, JD; Desai, AA; Sysol, JR; Abbasi, T; Patel, AR; Lang, RM; Gupta, A; Garcia, JGN; Gordeuk, VR; Machado, RF Genome-Wide Analysis Identifies IL-18 and FUCA2 as Novel Genes Associated with Diastolic Function in African Americans with Sickle Cell Disease. PLoS One, 11(9), e0163013. 2016.
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Elangovan, VRamamoorth; Camp, SM; Kelly, GT; Desai, AA; Adyshev, D; Sun, X; Black, SM; Wang, T; Garcia, JGN Endotoxin- and mechanical stress-induced epigenetic changes in the regulation of the nicotinamide phosphoribosyltransferase promoter. Pulm Circ, 6(4), 539-544. 2016.
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Indik, JH; Nair, V; Rafikov, R; Nyotowidjojo, IS; Bisla, J; Kansal, M; Parikh, DS; Robinson, M; Desai, A; Oberoi, M; Gupta, A; Abbasi, T; Khalpey, Z; Patel, AR; Lang, RM; Dudley, SC; Choi, BR; Garcia, JGN; Machado, RF; Desai, AA Associations of Prolonged QTc in Sickle Cell Disease. PLoS One, 11(10), e0164526. 2016.
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Mirsaeidi, M; Vu, A; Zhang, W; Arbieva, Z; Zhang, C; Abbasi, T; Hakim, A; Schraufnagel, D; Sweiss, N; Baughman, R; Garcia, JGN; Machado, RF Annexin A11 is associated with pulmonary fibrosis in African American patients with sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis, 33(4), 418-422. 2016.
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Mirsaeidi, M; Banoei, MMehdi; Nienow, CK; Abassi, T; Hakim, A; Schraufnagel, D; Winston, BW; Sweiss, N; Baughman, R; Garcia, JGN; Machado, R Plasma metabolomic profile in fibrosing pulmonary sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis, 33(1), 29-38. 2016.
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Rafikova, O; Meadows, ML; Kinchen, JM; Mohney, RP; Maltepe, E; Desai, AA; Yuan, JXJ; Garcia, JGN; Fineman, JR; Rafikov, R; Black, SM Metabolic Changes Precede the Development of Pulmonary Hypertension in the Monocrotaline Exposed Rat Lung. PLoS One, 11(3), e0150480. 2016.
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Saraf, SL; Oh, AL; Patel, PR; Jalundhwala, Y; Sweiss, K; Koshy, M; Campbell-Lee, S; Gowhari, M; Hassan, J; Peace, D; Quigley, JG; Khan, I; Molokie, RE; Hsu, LL; Mahmud, N; Levinson, DJ; Pickard, S; Garcia, JGN; Gordeuk, VR; Rondelli, D Nonmyeloablative Stem Cell Transplantation with Alemtuzumab/Low-Dose Irradiation to Cure and Improve the Quality of Life of Adults with Sickle Cell Disease. Biol Blood Marrow Transplant, 22(3), 441-8. 2016.
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Singla, S; Zhou, T; Javaid, K; Abbasi, T; Casanova, N; Zhang, W; Ma, SF; Wade, MS; Noth, I; Sweiss, NJ; Garcia, JGN; Machado, RF Expression profiling elucidates a molecular gene signature for pulmonary hypertension in sarcoidosis. Pulm Circ, 6(4), 465-471. 2016.
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Song, S; Jacobson, KN; McDermott, KM; Reddy, SP; Cress, AE; Tang, H; Dudek, SM; Black, SM; Garcia, JGN; Makino, A; Yuan, JXJ ATP promotes cell survival via regulation of cytosolic [Ca2+] and Bcl-2/Bax ratio in lung cancer cells. Am J Physiol Cell Physiol, 310(2), C99-114. 2016.
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Sun, X; Kellner, M; Desai, AA; Wang, T; Lu, Q; Kangath, A; Qu, N; Klinger, C; Fratz, S; Yuan, JXJ; Jacobson, JR; Garcia, JGN; Rafikov, R; Fineman, JR; Black, SM Asymmetric Dimethylarginine Stimulates Akt1 Phosphorylation via Heat Shock Protein 70-Facilitated Carboxyl-Terminal Modulator Protein Degradation in Pulmonary Arterial Endothelial Cells. Am J Respir Cell Mol Biol, 55(2), 275-87. 2016.
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Tang, H; Yamamura, A; Yamamura, H; Song, S; Fraidenburg, DR; Chen, J; Gu, Y; Pohl, NM; Zhou, T; Jiménez-Pérez, L; Ayon, RJ; Desai, AA; Goltzman, D; Rischard, F; Khalpey, Z; Black, SM; Garcia, JGN; Makino, A; Yuan, JXJ Pathogenic role of calcium-sensing receptors in the development and progression of pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol, 310(9), L846-59. 2016.
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Tao, S; de la Vega, MRojo; Quijada, H; Wondrak, GT; Wang, T; Garcia, JGN; Zhang, DD Bixin protects mice against ventilation-induced lung injury in an NRF2-dependent manner. Sci Rep, 6 18760. 2016.
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Viswanathan, P; Ephstein, Y; Garcia, JGN; Cho, M; Dudek, SM Differential elastic responses to barrier-altering agonists in two types of human lung endothelium. Biochem Biophys Res Commun, 478(2), 599-605. 2016.
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Wang, T; Mathew, B; Wu, X; Shimizu, Y; Rizzo, AN; Dudek, SM; Weichselbaum, RR; Jacobson, JR; Hecker, L; Garcia, JGN Nonmuscle myosin light chain kinase activity modulates radiation-induced lung injury. Pulm Circ, 6(2), 234-9. 2016.
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PMCID: PMC4869928.
Xie, L; Chiang, ET; Wu, X; Kelly, GT; Kanteti, P; Singleton, PA; Camp, SM; Zhou, T; Dudek, SM; Natarajan, V; Wang, T; Black, SM; Garcia, JGN; Jacobson, JR Regulation of Thrombin-Induced Lung Endothelial Cell Barrier Disruption by Protein Kinase C Delta. PLoS One, 11(7), e0158865. 2016.
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Zhang, X; Shah, BN; Zhang, W; Saraf, SL; Miasnikova, G; Sergueeva, A; Ammosova, T; Niu, X; Nouraie, M; Nekhai, S; Castro, O; Gladwin, MT; Prchal, JT; Garcia, JGN; Machado, RF; Gordeuk, VR A genetic variation associated with plasma erythropoietin and a non-coding transcript of PRKAR1A in sickle cell disease. Hum Mol Genet, . 2016.
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Acosta-Herrera, M; Pino-Yanes, M; Ma, SF; Barreto-Luis, A; Corrales, A; Cumplido, J; Pérez-Rodríguez, E; Campo, P; Eng, C; García-Robaina, JCarlos; Quintela, I; Villar, J; Blanca, M; Carracedo, Á; Carrillo, T; Garcia, JGN; Torgerson, DG; Burchard, EG; Flores, C Fine mapping of the myosin light chain kinase (MYLK) gene replicates the association with asthma in populations of Spanish descent. J Allergy Clin Immunol, 136(4), 1116-8.e9. 2015.
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Audrito, V; Serra, S; Brusa, D; Mazzola, F; Arruga, F; Vaisitti, T; Coscia, M; Maffei, R; Rossi, D; Wang, T; Inghirami, G; Rizzi, M; Gaidano, G; Garcia, JGN; Wolberger, C; Raffaelli, N; Deaglio, S Extracellular nicotinamide phosphoribosyltransferase (NAMPT) promotes M2 macrophage polarization in chronic lymphocytic leukemia. Blood, 125(1), 111-23. 2015.
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Camp, SM; Chiang, ET; Sun, C; Usatyuk, PV; Bittman, R; Natarajan, V; Garcia, JGN; Dudek, SM Pulmonary endothelial cell barrier enhancement by novel FTY720 analogs: methoxy-FTY720, fluoro-FTY720, and β-glucuronide-FTY720. Chem Phys Lipids, 191 16-24. 2015.
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Camp, SM; Ceco, E; Evenoski, CL; Danilov, SM; Zhou, T; Chiang, ET; Moreno-Vinasco, L; Mapes, B; Zhao, J; Gursoy, G; Brown, ME; Adyshev, DM; Siddiqui, SS; Quijada, H; Sammani, S; Letsiou, E; Saadat, L; Yousef, M; Wang, T; Liang, J; Garcia, JGN Unique Toll-Like Receptor 4 Activation by NAMPT/PBEF Induces NFκB Signaling and Inflammatory Lung Injury. Sci Rep, 5 13135. 2015.
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Casanova, N; Zhou, T; Knox, KS; Garcia, JGN Identifying Novel Biomarkers in Sarcoidosis Using Genome-Based Approaches. Clin Chest Med, 36(4), 621-630. 2015.
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Chen, W; Epshtein, Y; Ni, X; Dull, RO; Cress, AE; Garcia, JGN; Jacobson, JR Role of Integrin β4 in Lung Endothelial Cell Inflammatory Responses to Mechanical Stress. Sci Rep, 5 16529. 2015.
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Choi, S; Camp, SM; Dan, A; Garcia, JGN; Dudek, SM; Leckband, DE A genetic variant of cortactin linked to acute lung injury impairs lamellipodia dynamics and endothelial wound healing. Am J Physiol Lung Cell Mol Physiol, 309(9), L983-94. 2015.
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Feldman, AM; Runge, MS; Garcia, JGN; Rubenstein, AH American medical education at a crossroads. Sci Transl Med, 7(285), 285fs17. 2015.
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Fu, P; Usatyuk, PV; Lele, A; Harijith, A; Gregorio, CC; Garcia, JGN; Salgia, R; Natarajan, V c-Abl mediated tyrosine phosphorylation of paxillin regulates LPS-induced endothelial dysfunction and lung injury. Am J Physiol Lung Cell Mol Physiol, 308(10), L1025-38. 2015.
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Huang, Y; Ma, SF; Vij, R; Oldham, JM; Herazo-Maya, J; Broderick, SM; Strek, ME; White, SR; Hogarth, K; Sandbo, NK; Lussier, YA; Gibson, KF; Kaminski, N; Garcia, JGN; Noth, I A functional genomic model for predicting prognosis in idiopathic pulmonary fibrosis. BMC Pulm Med, 15 147. 2015.
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Huang, LShuang; Berdyshev, EV; Tran, JT; Xie, L; Chen, J; Ebenezer, DL; Mathew, B; Gorshkova, I; Zhang, W; Reddy, SP; Harijith, A; Wang, G; Feghali-Bostwick, C; Noth, I; Ma, SF; Zhou, T; Ma, W; Garcia, JGN; Natarajan, V Sphingosine-1-phosphate lyase is an endogenous suppressor of pulmonary fibrosis: role of S1P signalling and autophagy. Thorax, 70(12), 1138-48. 2015.
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Khalpey, Z; Qu, N; Hemphill, C; Louis, AV; Ferng, AS; Son, TG; Stavoe, K; Penick, K; Tran, PL; Konhilas, J; Lagrand, DS; Garcia, JGN Rapid porcine lung decellularization using a novel organ regenerative control acquisition bioreactor. ASAIO J, 61(1), 71-7. 2015.
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Letsiou, E; Rizzo, AN; Sammani, S; Naureckas, P; Jacobson, JR; Garcia, JGN; Dudek, SM Differential and opposing effects of imatinib on LPS- and ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol, 308(3), L259-69. 2015.
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Letsiou, E; Sammani, S; Zhang, W; Zhou, T; Quijada, H; Moreno-Vinasco, L; Dudek, SM; Garcia, JGN Pathologic mechanical stress and endotoxin exposure increases lung endothelial microparticle shedding. Am J Respir Cell Mol Biol, 52(2), 193-204. 2015.
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Li, H; Pouladi, N; Achour, I; Gardeux, V; Li, J; Li, Q; Zhang, HHelen; Martinez, FD; Garcia, JGN 'Skip'; Lussier, YA eQTL networks unveil enriched mRNA master integrators downstream of complex disease-associated SNPs. J Biomed Inform, 58 226-234. 2015.
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Mathew, B; Takekoshi, D; Sammani, S; Epshtein, Y; Sharma, R; Smith, BD; Mitra, S; Desai, AA; Weichselbaum, RR; Garcia, JGN; Jacobson, JR Role of GADD45a in murine models of radiation- and bleomycin-induced lung injury. Am J Physiol Lung Cell Mol Physiol, 309(12), L1420-9. 2015.
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Qian, Z; Zhou, T; Gurguis, CI; Xu, X; Wen, Q; Lv, J; Fang, F; Hecker, L; Cress, AE; Natarajan, V; Jacobson, JR; Zhang, DD; Garcia, JGN; Wang, T Nuclear factor, erythroid 2-like 2-associated molecular signature predicts lung cancer survival. Sci Rep, 5 16889. 2015.
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Rizzo, AN; Sammani, S; Esquinca, AE; Jacobson, JR; Garcia, JGN; Letsiou, E; Dudek, SM Imatinib attenuates inflammation and vascular leak in a clinically relevant two-hit model of acute lung injury. Am J Physiol Lung Cell Mol Physiol, 309(11), L1294-304. 2015.
PMID: 26432864.
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Schell-Chaple, HM; Puntillo, KA; Matthay, MA; Liu, KD Body temperature and mortality in patients with acute respiratory distress syndrome. Am J Crit Care, 24(1), 15-23. 2015.
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PMCID: PMC4464553.
Shen, K; Ramirez, B; Mapes, B; Shen, GR; Gokhale, V; Brown, ME; Santarsiero, B; Ishii, Y; Dudek, SM; Wang, T; Garcia, JGN Structure-Function Analysis of the Non-Muscle Myosin Light Chain Kinase (nmMLCK) Isoform by NMR Spectroscopy and Molecular Modeling: Influence of MYLK Variants. PLoS One, 10(6), e0130515. 2015.
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PMCID: PMC4482139.
Tang, H; Chen, J; Fraidenburg, DR; Song, S; Sysol, JR; Drennan, AR; Offermanns, S; Ye, RD; Bonini, MG; Minshall, RD; Garcia, JGN; Machado, RF; Makino, A; Yuan, JXJ Deficiency of Akt1, but not Akt2, attenuates the development of pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol, 308(2), L208-20. 2015.
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Zhang, X; Zhang, W; Saraf, SL; Nouraie, M; Han, J; Gowhari, M; Hassan, J; Miasnikova, G; Sergueeva, A; Nekhai, S; Kittles, R; Machado, RF; Garcia, JGN; Gladwin, MT; Steinberg, MH; Sebastiani, P; McClain, DA; Gordeuk, VR Genetic polymorphism of APOB is associated with diabetes mellitus in sickle cell disease. Hum Genet, 134(8), 895-904. 2015.
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Adyshev, DM; Elangovan, VRamamoorth; Moldobaeva, N; Mapes, B; Sun, X; Garcia, JGN Mechanical stress induces pre-B-cell colony-enhancing factor/NAMPT expression via epigenetic regulation by miR-374a and miR-568 in human lung endothelium. Am J Respir Cell Mol Biol, 50(2), 409-18. 2014.
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Belvitch, P; Adyshev, D; Elangovan, VR; Brown, ME; Naureckas, C; Rizzo, AN; Siegler, JH; Garcia, JGN; Dudek, SM Proline-rich region of non-muscle myosin light chain kinase modulates kinase activity and endothelial cytoskeletal dynamics. Microvasc Res, 95 94-102. 2014.
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PMCID: PMC4188692.
Calfee, CS; Delucchi, K; Parsons, PE; Thompson, T; Ware, LB; Matthay, MA Subphenotypes in acute respiratory distress syndrome: latent class analysis of data from two randomised controlled trials. Lancet Respir Med, 2(8), 611-20. 2014.
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Chen, W; Sharma, R; Rizzo, AN; Siegler, JH; Garcia, JGN; Jacobson, JR Role of claudin-5 in the attenuation of murine acute lung injury by simvastatin. Am J Respir Cell Mol Biol, 50(2), 328-36. 2014.
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PMCID: PMC3930946.
Chen, J; Tang, H; Sysol, JR; Moreno-Vinasco, L; Shioura, KM; Chen, T; Gorshkova, I; Wang, L; Huang, LShuang; Usatyuk, PV; Sammani, S; Zhou, G; Raj, U; Garcia, JGN; Berdyshev, E; Yuan, JXJ; Natarajan, V; Machado, RF The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension. Am J Respir Crit Care Med, 190(9), 1032-43. 2014.
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Danilov, SM; Wade, MS; Schwager, SL; Douglas, RG; Nesterovitch, AB; Popova, IA; Hogarth, KD; Bhardwaj, N; Schwartz, DE; Sturrock, ED; Garcia, JGN A novel angiotensin I-converting enzyme mutation (S333W) impairs N-domain enzymatic cleavage of the anti-fibrotic peptide, AcSDKP. PLoS One, 9(2), e88001. 2014.
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PMCID: PMC3913711.
Desai, AA; Patel, AR; Ahmad, H; Groth, JV; Thiruvoipati, T; Turner, K; Yodwut, C; Czobor, P; Artz, N; Machado, RF; Garcia, JGN; Lang, RM Mechanistic insights and characterization of sickle cell disease-associated cardiomyopathy. Circ Cardiovasc Imaging, 7(3), 430-437. 2014.
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Eadon, MT; Jacob, A; Cunningham, PN; Quigg, RJ; Garcia, JGN; Alexander, JJ Transcriptional profiling reveals that C5a alters microRNA in brain endothelial cells. Immunology, 143(3), 363-73. 2014.
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Gardeux, V; Achour, I; Li, J; Maienschein-Cline, M; Li, H; Pesce, L; Parinandi, G; Bahroos, N; Winn, R; Foster, I; Garcia, JGN; Lussier, YA 'N-of-1-pathways' unveils personal deregulated mechanisms from a single pair of RNA-Seq samples: towards precision medicine. J Am Med Inform Assoc, 21(6), 1015-25. 2014.
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Goldman, JL; Sammani, S; Kempf, C; Saadat, L; Letsiou, E; Wang, T; Moreno-Vinasco, L; Rizzo, AN; Fortman, JD; Garcia, JGN Pleiotropic effects of interleukin-6 in a "two-hit" murine model of acute respiratory distress syndrome. Pulm Circ, 4(2), 280-8. 2014.
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Han, MLK; Zhou, Y; Murray, S; Tayob, N; Noth, I; Lama, VN; Moore, BB; White, ES; Flaherty, KR; Huffnagle, GB; Martinez, FJ Lung microbiome and disease progression in idiopathic pulmonary fibrosis: an analysis of the COMET study. Lancet Respir Med, 2(7), 548-56. 2014.
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Huang, LShuang; Mathew, B; Li, H; Zhao, Y; Ma, SF; Noth, I; Reddy, SP; Harijith, A; Usatyuk, PV; Berdyshev, EV; Kaminski, N; Zhou, T; Zhang, W; Zhang, Y; Rehman, J; Kotha, SR; Gurney, TO; Parinandi, NL; Lussier, YA; Garcia, JGN; Natarajan, V The mitochondrial cardiolipin remodeling enzyme lysocardiolipin acyltransferase is a novel target in pulmonary fibrosis. Am J Respir Crit Care Med, 189(11), 1402-15. 2014.
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Moreno-Vinasco, L; Quijada, H; Sammani, S; Siegler, J; Letsiou, E; Deaton, R; Saadat, L; Zaidi, RS; Messana, J; Gann, PH; Machado, RF; Ma, W; Camp, SM; Wang, T; Garcia, JGN Nicotinamide phosphoribosyltransferase inhibitor is a novel therapeutic candidate in murine models of inflammatory lung injury. Am J Respir Cell Mol Biol, 51(2), 223-8. 2014.
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Ni, X; Epshtein, Y; Chen, W; Zhou, T; Xie, L; Garcia, JGN; Jacobson, JR Interaction of integrin β4 with S1P receptors in S1P- and HGF-induced endothelial barrier enhancement. J Cell Biochem, 115(6), 1187-95. 2014.
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Sun, X; Elangovan, VRamamoorth; Mapes, B; Camp, SM; Sammani, S; Saadat, L; Ceco, E; Ma, SF; Flores, C; MacDougall, MS; Quijada, H; Liu, B; Kempf, CL; Wang, T; Chiang, ET; Garcia, JGN The NAMPT promoter is regulated by mechanical stress, signal transducer and activator of transcription 5, and acute respiratory distress syndrome-associated genetic variants. Am J Respir Cell Mol Biol, 51(5), 660-7. 2014.
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Sweiss, NJ; Noth, I; Mirsaeidi, M; Zhang, W; Naureckas, ET; Hogarth, K; Strek, M; Caligiuri, P; Machado, RF; Niewold, TB; Garcia, JGN; Pangan, AL; Baughman, RP Efficacy Results of a 52-week Trial of Adalimumab in the Treatment of Refractory Sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis, 31(1), 46-54. 2014.
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Sweiss, NJ; Lower, EE; Mirsaeidi, M; Dudek, S; Garcia, JGN; Perkins, D; Finn, PW; Baughman, RP Rituximab in the treatment of refractory pulmonary sarcoidosis. Eur Respir J, 43(5), 1525-8. 2014.
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Usatyuk, PV; Fu, P; Mohan, V; Epshtein, Y; Jacobson, JR; Gomez-Cambronero, J; Wary, KK; Bindokas, V; Dudek, SM; Salgia, R; Garcia, JGN; Natarajan, V Role of c-Met/phosphatidylinositol 3-kinase (PI3k)/Akt signaling in hepatocyte growth factor (HGF)-mediated lamellipodia formation, reactive oxygen species (ROS) generation, and motility of lung endothelial cells. J Biol Chem, 289(19), 13476-91. 2014.
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Wang, L; Sammani, S; Moreno-Vinasco, L; Letsiou, E; Wang, T; Camp, SM; Bittman, R; Garcia, JGN; Dudek, SM FTY720 (s)-phosphonate preserves sphingosine 1-phosphate receptor 1 expression and exhibits superior barrier protection to FTY720 in acute lung injury. Crit Care Med, 42(3), e189-99. 2014.
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Wang, T; Moreno-Vinasco, L; Ma, SF; Zhou, T; Shimizu, Y; Sammani, S; Epshtein, Y; Watterson, M; Dudek, SM; Garcia, JGN Nonmuscle myosin light chain kinase regulates murine asthmatic inflammation. Am J Respir Cell Mol Biol, 50(6), 1129-35. 2014.
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Zhang, X; Zhang, W; Ma, SF; Desai, AA; Saraf, S; Miasniakova, G; Sergueeva, A; Ammosova, T; Xu, M; Nekhai, S; Abbasi, T; Casanova, NG; Steinberg, MH; Baldwin, CT; Sebastiani, P; Prchal, JT; Kittles, R; Garcia, JGN; Machado, RF; Gordeuk, VR Hypoxic response contributes to altered gene expression and precapillary pulmonary hypertension in patients with sickle cell disease. Circulation, 129(16), 1650-8. 2014.
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Zhang, X; Zhang, W; Ma, SF; Miasniakova, G; Sergueeva, A; Ammosova, T; Xu, M; Nekhai, S; Nourai, M; Wade, MS; Prchal, JT; Garcia, JGN; Machado, RF; Gordeuk, VR Iron deficiency modifies gene expression variation induced by augmented hypoxia sensing. Blood Cells Mol Dis, 52(1), 35-45. 2014.
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Adyshev, DM; Dudek, SM; Moldobaeva, N; Kim, Kmi; Ma, SF; Kasa, A; Garcia, JGN; Verin, AD Ezrin/radixin/moesin proteins differentially regulate endothelial hyperpermeability after thrombin. Am J Physiol Lung Cell Mol Physiol, 305(3), L240-55. 2013.
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Adyshev, DM; Moldobaeva, N; Mapes, B; Elangovan, V; Garcia, JGN MicroRNA regulation of nonmuscle myosin light chain kinase expression in human lung endothelium. Am J Respir Cell Mol Biol, 49(1), 58-66. 2013.
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Arce, FTerán; Meckes, B; Camp, SM; Garcia, JGN; Dudek, SM; Lal, R Heterogeneous elastic response of human lung microvascular endothelial cells to barrier modulating stimuli. Nanomedicine, 9(7), 875-84. 2013.
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Bress, A; Han, J; Patel, SR; Desai, AA; Mansour, I; Groo, V; Progar, K; Shah, E; Stamos, TD; Wing, C; Garcia, JGN; Kittles, R; Cavallari, LH Association of aldosterone synthase polymorphism (CYP11B2 -344T>C) and genetic ancestry with atrial fibrillation and serum aldosterone in African Americans with heart failure. PLoS One, 8(7), e71268. 2013.
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Chen, J; Feng, G; Guo, Q; Wardenburg, JB; Lin, S; Inoshima, I; Deaton, R; Yuan, JXJ; Garcia, JGN; Machado, RF; Otto, M; Wunderink, RG Transcriptional events during the recovery from MRSA lung infection: a mouse pneumonia model. PLoS One, 8(8), e70176. 2013.
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Ephstein, Y; Singleton, PA; Chen, W; Wang, L; Salgia, R; Kanteti, P; Dudek, SM; Garcia, JGN; Jacobson, JR Critical role of S1PR1 and integrin β4 in HGF/c-Met-mediated increases in vascular integrity. J Biol Chem, 288(4), 2191-200. 2013.
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Herazo-Maya, JD; Noth, I; Duncan, SR; Kim, S; Ma, SF; Tseng, GC; Feingold, E; Juan-Guardela, BM; Richards, TJ; Lussier, Y; Huang, Y; Vij, R; Lindell, KO; Xue, J; Gibson, KF; Shapiro, SD; Garcia, JGN; Kaminski, N Peripheral blood mononuclear cell gene expression profiles predict poor outcome in idiopathic pulmonary fibrosis. Sci Transl Med, 5(205), 205ra136. 2013.
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Huang, LShuang; Fu, P; Patel, P; Harijith, A; Sun, T; Zhao, Y; Garcia, JGN; Chun, J; Natarajan, V Lysophosphatidic acid receptor-2 deficiency confers protection against bleomycin-induced lung injury and fibrosis in mice. Am J Respir Cell Mol Biol, 49(6), 912-22. 2013.
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Huang, LShuang; Berdyshev, E; Mathew, B; Fu, P; Gorshkova, IA; He, D; Ma, W; Noth, I; Ma, SF; Pendyala, S; Reddy, SP; Zhou, T; Zhang, W; Garzon, SA; Garcia, JGN; Natarajan, V Targeting sphingosine kinase 1 attenuates bleomycin-induced pulmonary fibrosis. FASEB J, 27(4), 1749-60. 2013.
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Liu, B; Sun, X; Suyeoka, G; Garcia, JGN; Leiderman, YI TGFβ signaling induces expression of Gadd45b in retinal ganglion cells. Invest Ophthalmol Vis Sci, 54(2), 1061-9. 2013.
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Man, M; Close, SL; Shaw, AD; Bernard, GR; Douglas, IS; Kaner, RJ; Payen, D; Vincent, JL; Fossceco, S; Janes, JM; Leishman, AG; O'Brien, L; Williams, MD; Garcia, JGN Beyond single-marker analyses: mining whole genome scans for insights into treatment responses in severe sepsis. Pharmacogenomics J, 13(3), 218-26. 2013.
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Mathew, B; Jacobson, JR; Siegler, JH; Moitra, J; Blasco, M; Xie, L; Unzueta, C; Zhou, T; Evenoski, C; Al-Sakka, M; Sharma, R; Huey, B; Bulent, A; Smith, B; Jayaraman, S; Reddy, NM; Reddy, SP; Fingerle-Rowson, G; Bucala, R; Dudek, SM; Natarajan, V; Weichselbaum, RR; Garcia, JGN Role of migratory inhibition factor in age-related susceptibility to radiation lung injury via NF-E2-related factor-2 and antioxidant regulation. Am J Respir Cell Mol Biol, 49(2), 269-78. 2013.
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Natarajan, V; Dudek, SM; Jacobson, JR; Moreno-Vinasco, L; Huang, LShuang; Abassi, T; Mathew, B; Zhao, Y; Wang, L; Bittman, R; Weichselbaum, R; Berdyshev, E; Garcia, JGN Sphingosine-1-phosphate, FTY720, and sphingosine-1-phosphate receptors in the pathobiology of acute lung injury. Am J Respir Cell Mol Biol, 49(1), 6-17. 2013.
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Noth, I; Zhang, Y; Ma, SF; Flores, C; Barber, M; Huang, Y; Broderick, SM; Wade, MS; Hysi, P; Scuirba, J; Richards, TJ; Juan-Guardela, BM; Vij, R; Han, MLK; Martinez, FJ; Kossen, K; Seiwert, SD; Christie, JD; Nicolae, D; Kaminski, N; Garcia, JGN Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study. Lancet Respir Med, 1(4), 309-317. 2013.
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Nutescu, EA; Drozda, K; Bress, AP; Galanter, WL; Stevenson, J; Stamos, TD; Desai, AA; Duarte, JD; Gordeuk, V; Peace, D; Kadkol, SS; Dodge, C; Saraf, S; Garofalo, J; Krishnan, JA; Garcia, JGN; Cavallari, LH Feasibility of implementing a comprehensive warfarin pharmacogenetics service. Pharmacotherapy, 33(11), 1156-64. 2013.
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Peljto, AL; Zhang, Y; Fingerlin, TE; Ma, SF; Garcia, JGN; Richards, TJ; Silveira, LJ; Lindell, KO; Steele, MP; Loyd, JE; Gibson, KF; Seibold, MA; Brown, KK; Talbert, JL; Markin, C; Kossen, K; Seiwert, SD; Murphy, E; Noth, I; Schwarz, MI; Kaminski, N; Schwartz, DA Association between the MUC5B promoter polymorphism and survival in patients with idiopathic pulmonary fibrosis. JAMA, 309(21), 2232-9. 2013.
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Pillai, VB; Sundaresan, NR; Kim, G; Samant, S; Moreno-Vinasco, L; Garcia, JGN; Gupta, MP Nampt secreted from cardiomyocytes promotes development of cardiac hypertrophy and adverse ventricular remodeling. Am J Physiol Heart Circ Physiol, 304(3), H415-26. 2013.
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Sun, X; Ma, SF; Wade, MS; Acosta-Herrera, M; Villar, J; Pino-Yanes, M; Zhou, T; Liu, B; Belvitch, P; Moitra, J; Han, YJ; Machado, R; Noth, I; Natarajan, V; Dudek, SM; Jacobson, JR; Flores, C; Garcia, JGN Functional promoter variants in sphingosine 1-phosphate receptor 3 associate with susceptibility to sepsis-associated acute respiratory distress syndrome. Am J Physiol Lung Cell Mol Physiol, 305(7), L467-77. 2013.
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Sysol, JR; Kempf, C; Helton, MN; Dong, Y; Zhu, D; Sun, H; Garcia, JGN; Machado, RF; Chen, J Evaluation of a reliable and cost-effective method of DNA isolation for mouse genotyping. Biotechnol Lett, 35(4), 509-14. 2013.
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Usatyuk, PV; Burns, M; Mohan, V; Pendyala, S; He, D; Ebenezer, DL; Harijith, A; Fu, P; Huang, LShuang; Bear, JE; Garcia, JGN; Natarajan, V Coronin 1B regulates S1P-induced human lung endothelial cell chemotaxis: role of PLD2, protein kinase C and Rac1 signal transduction. PLoS One, 8(5), e63007. 2013.
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Zhang, W; Zhou, T; Ma, SF; Machado, RF; Bhorade, SM; Garcia, JGN MicroRNAs Implicated in Dysregulation of Gene Expression Following Human Lung Transplantation. Transl Respir Med, 1(1), . 2013.
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Ahmad, H; Gayat, E; Yodwut, C; Abduch, C; Patel, AR; Weinert, L; Desai, A; Tsang, W; Garcia, JGN; Lang, RM; Mor-Avi, V Evaluation of myocardial deformation in patients with sickle cell disease and preserved ejection fraction using three-dimensional speckle tracking echocardiography. Echocardiography, 29(8), 962-9. 2012.
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Ashley, EA; Hershberger, RE; Caleshu, C; Ellinor, PT; Garcia, JGN; Herrington, DM; Ho, CY; Johnson, JA; Kittner, SJ; Macrae, CA; Mudd-Martin, G; Rader, DJ; Roden, DM; Scholes, D; Sellke, FW; Towbin, JA; Van Eyk, J; Worrall, BB Genetics and cardiovascular disease: a policy statement from the American Heart Association. Circulation, 126(1), 142-57. 2012.
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Calfee, CS; Gallagher, D; Abbott, J; Thompson, T; Matthay, MA Plasma angiopoietin-2 in clinical acute lung injury: prognostic and pathogenetic significance. Crit Care Med, 40(6), 1731-7. 2012.
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Chen, W; Sammani, S; Mitra, S; Ma, SFan; Garcia, JGN; Jacobson, JR Critical role for integrin-β4 in the attenuation of murine acute lung injury by simvastatin. Am J Physiol Lung Cell Mol Physiol, 303(4), L279-85. 2012.
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Desai, AA; Zhou, T; Ahmad, H; Zhang, W; Mu, W; Trevino, S; Wade, MS; Raghavachari, N; Kato, GJ; Peters-Lawrence, MH; Thiruvoipati, T; Turner, K; Artz, N; Huang, Y; Patel, AR; Yuan, JXJ; Gordeuk, VR; Lang, RM; Garcia, JGN; Machado, RF A novel molecular signature for elevated tricuspid regurgitation velocity in sickle cell disease. Am J Respir Crit Care Med, 186(4), 359-68. 2012.
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Dessap, AMekontso; Voiriot, G; Zhou, T; Marcos, E; Dudek, SM; Jacobson, JR; Machado, R; Adnot, S; Brochard, L; Maitre, B; Garcia, JGN Conflicting physiological and genomic cardiopulmonary effects of recruitment maneuvers in murine acute lung injury. Am J Respir Cell Mol Biol, 46(4), 541-50. 2012.
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Flores, C; Ma, SF; Pino-Yanes, M; Wade, MS; Pérez-Méndez, L; Kittles, RA; Wang, D; Papaiahgari, S; Ford, JG; Kumar, R; Garcia, JGN African ancestry is associated with asthma risk in African Americans. PLoS One, 7(1), e26807. 2012.
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Frank, KM; Zhou, T; Moreno-Vinasco, L; Hollett, B; Garcia, JGN; Wardenburg, JBubeck Host response signature to Staphylococcus aureus alpha-hemolysin implicates pulmonary Th17 response. Infect Immun, 80(9), 3161-9. 2012.
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Gorshkova, I; Zhou, T; Mathew, B; Jacobson, JR; Takekoshi, D; Bhattacharya, P; Smith, B; Aydogan, B; Weichselbaum, RR; Natarajan, V; Garcia, JGN; Berdyshev, EV Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression. J Lipid Res, 53(8), 1553-68. 2012.
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Patel, AR; Ahmad, H; Desai, AA; Thiruvoipati, T; Turner, KM; Weinert, L; Yodwut, C; Czobor, P; Artz, N; Trevino, S; Mor-Avi, V; Machado, R; Garcia, JG; Lang, R Mechanistic insights and characterization of cardiomyopathy due to Sickle Cell Disease J Cardiovasc Magn Reson, 14 Suppl 1 O78. 2012.
Petrov, MN; Shilo, VY; Tarasov, AV; Schwartz, DE; Garcia, JGN; Kost, OA; Danilov, SM Conformational changes of blood ACE in chronic uremia. PLoS One, 7(11), e49290. 2012.
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Pitroda, SP; Zhou, T; Sweis, RF; Filippo, M; Labay, E; Beckett, MA; Mauceri, HJ; Liang, H; Darga, TE; Perakis, S; Khan, SA; Sutton, HG; Zhang, W; Khodarev, NN; Garcia, JGN; Weichselbaum, RR Tumor endothelial inflammation predicts clinical outcome in diverse human cancers. PLoS One, 7(10), e46104. 2012.
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Sun, X; Singleton, PA; Letsiou, E; Zhao, J; Belvitch, P; Sammani, S; Chiang, ET; Moreno-Vinasco, L; Wade, MS; Zhou, T; Liu, B; Parastatidis, I; Thomson, L; Ischiropoulos, H; Natarajan, V; Jacobson, JR; Machado, RF; Dudek, SM; Garcia, JGN Sphingosine-1-phosphate receptor-3 is a novel biomarker in acute lung injury. Am J Respir Cell Mol Biol, 47(5), 628-36. 2012.
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Usatyuk, PV; Singleton, PA; Pendyala, S; Kalari, SK; He, D; Gorshkova, IA; Camp, SM; Moitra, J; Dudek, SM; Garcia, JGN; Natarajan, V Novel role for non-muscle myosin light chain kinase (MLCK) in hyperoxia-induced recruitment of cytoskeletal proteins, NADPH oxidase activation, and reactive oxygen species generation in lung endothelium. J Biol Chem, 287(12), 9360-75. 2012.
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Valentine, SL; Sapru, A; Higgerson, RA; Spinella, PC; Flori, HR; Graham, DA; Brett, M; Convery, M; Christie, LAM; Karamessinis, L; Randolph, AG Fluid balance in critically ill children with acute lung injury. Crit Care Med, 40(10), 2883-9. 2012.
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Wang, T; Wang, L; Zaidi, SR; Sammani, S; Siegler, J; Moreno-Vinasco, L; Mathew, B; Natarajan, V; Garcia, JGN Hydrogen sulfide attenuates particulate matter-induced human lung endothelial barrier disruption via combined reactive oxygen species scavenging and Akt activation. Am J Respir Cell Mol Biol, 47(4), 491-6. 2012.
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Wang, T; Wang, L; Moreno-Vinasco, L; Lang, GD; Siegler, JH; Mathew, B; Usatyuk, PV; Samet, JM; Geyh, AS; Breysse, PN; Natarajan, V; Garcia, JGN Particulate matter air pollution disrupts endothelial cell barrier via calpain-mediated tight junction protein degradation. Part Fibre Toxicol, 9 35. 2012.
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Wang, T; Lang, GD; Moreno-Vinasco, L; Huang, Y; Goonewardena, SN; Peng, YJ; Svensson, EC; Natarajan, V; Lang, RM; Linares, JD; Breysse, PN; Geyh, AS; Samet, JM; Lussier, YA; Dudley, S; Prabhakar, NR; Garcia, JGN Particulate matter induces cardiac arrhythmias via dysregulation of carotid body sensitivity and cardiac sodium channels. Am J Respir Cell Mol Biol, 46(4), 524-31. 2012.
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Zhou, T; Zhang, W; Sweiss, NJ; Chen, ES; Moller, DR; Knox, KS; Ma, SF; Wade, MS; Noth, I; Machado, RF; Garcia, JGN Peripheral blood gene expression as a novel genomic biomarker in complicated sarcoidosis. PLoS One, 7(9), e44818. 2012.
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Barca-Mayo, O; Liao, XH; DiCosmo, C; Dumitrescu, A; Moreno-Vinasco, L; Wade, MS; Sammani, S; Mirzapoiazova, T; Garcia, JGN; Refetoff, S; Weiss, RE Role of type 2 deiodinase in response to acute lung injury (ALI) in mice. Proc Natl Acad Sci U S A, 108(49), E1321-9. 2011.
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Berdyshev, EV; Gorshkova, I; Usatyuk, P; Kalari, S; Zhao, Y; Pyne, NJ; Pyne, S; Sabbadini, RA; Garcia, JGN; Natarajan, V Intracellular S1P generation is essential for S1P-induced motility of human lung endothelial cells: role of sphingosine kinase 1 and S1P lyase. PLoS One, 6(1), e16571. 2011.
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Calfee, CS; Ware, LB; Glidden, DV; Eisner, MD; Parsons, PE; Thompson, T; Matthay, MA Use of risk reclassification with multiple biomarkers improves mortality prediction in acute lung injury. Crit Care Med, 39(4), 711-7. 2011.
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Han, YJeong; Ma, SFan; Yourek, G; Park, YD; Garcia, JGN A transcribed pseudogene of MYLK promotes cell proliferation. FASEB J, 25(7), 2305-12. 2011.
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Liu, KD; Thompson, T; Ancukiewicz, M; Steingrub, JS; Douglas, IS; Matthay, MA; Wright, P; Peterson, MW; Rock, P; Hyzy, RC; Anzueto, A; Truwit, JD Acute kidney injury in patients with acute lung injury: impact of fluid accumulation on classification of acute kidney injury and associated outcomes. Crit Care Med, 39(12), 2665-71. 2011.
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Mathew, B; Lennon, FE; Siegler, J; Mirzapoiazova, T; Mambetsariev, N; Sammani, S; Gerhold, LM; LaRiviere, PJ; Chen, CT; Garcia, JGN; Salgia, R; Moss, J; Singleton, PA The novel role of the mu opioid receptor in lung cancer progression: a laboratory investigation. Anesth Analg, 112(3), 558-67. 2011.
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Mathew, B; Jacobson, JR; Berdyshev, E; Huang, Y; Sun, X; Zhao, Y; Gerhold, LM; Siegler, J; Evenoski, C; Wang, T; Zhou, T; Zaidi, R; Moreno-Vinasco, L; Bittman, R; Chen, CTu; LaRiviere, PJ; Sammani, S; Lussier, YA; Dudek, SM; Natarajan, V; Weichselbaum, RR; Garcia, JGN Role of sphingolipids in murine radiation-induced lung injury: protection by sphingosine 1-phosphate analogs. FASEB J, 25(10), 3388-400. 2011.
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Mathew, B; Huang, Y; Jacobson, JR; Berdyshev, E; Gerhold, LM; Wang, T; Moreno-Vinasco, L; Lang, G; Zhao, Y; Chen, CTu; LaRiviere, PJ; Mauceri, H; Sammani, S; Husain, AN; Dudek, SM; Natarajan, V; Lussier, YA; Weichselbaum, RR; Garcia, JGN Simvastatin attenuates radiation-induced murine lung injury and dysregulated lung gene expression. Am J Respir Cell Mol Biol, 44(3), 415-22. 2011.
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Mitra, S; Sammani, S; Wang, T; Boone, DL; Meyer, NJ; Dudek, SM; Moreno-Vinasco, L; Garcia, JGN; Jacobson, JR Role of growth arrest and DNA damage-inducible α in Akt phosphorylation and ubiquitination after mechanical stress-induced vascular injury. Am J Respir Crit Care Med, 184(9), 1030-40. 2011.
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Pendyala, S; Moitra, J; Kalari, S; Kleeberger, SR; Zhao, Y; Reddy, SP; Garcia, JGN; Natarajan, V Nrf2 regulates hyperoxia-induced Nox4 expression in human lung endothelium: identification of functional antioxidant response elements on the Nox4 promoter. Free Radic Biol Med, 50(12), 1749-59. 2011.
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Pino-Yanes, M; Ma, SF; Sun, X; Tejera, P; Corrales, A; Blanco, J; Pérez-Méndez, L; Espinosa, E; Muriel, A; Blanch, L; Garcia, JGN; Villar, J; Flores, C Interleukin-1 receptor-associated kinase 3 gene associates with susceptibility to acute lung injury. Am J Respir Cell Mol Biol, 45(4), 740-5. 2011.
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PMID: 21617203.
PMCID: PMC3262681.
Sweiss, NJ; Zhang, W; Franek, BS; Kariuki, SN; Moller, DR; Patterson, KC; Bennett, P; Girijala, LR; Nair, V; Baughman, RP; Garcia, JGN; Niewold, TB Linkage of type I interferon activity and TNF-alpha levels in serum with sarcoidosis manifestations and ancestry. PLoS One, 6(12), e29126. 2011.
PMID: 22195005
PMCID: PMC3237595.
Usatyuk, PV; He, D; Bindokas, V; Gorshkova, IA; Berdyshev, EV; Garcia, JGN; Natarajan, V Photolysis of caged sphingosine-1-phosphate induces barrier enhancement and intracellular activation of lung endothelial cell signaling pathways. Am J Physiol Lung Cell Mol Physiol, 300(6), L840-50. 2011.
PMID: 21478254.
PMCID: PMC3119122.
Wang, L; Chiang, ET; Simmons, JT; Garcia, JGN; Dudek, SM FTY720-induced human pulmonary endothelial barrier enhancement is mediated by c-Abl. Eur Respir J, 38(1), 78-88. 2011.
PMID: 21071472.
PMCID: PMC3758235.
Yao, W; Mu, W; Zeifman, A; Lofti, M; Remillard, CV; Makino, A; Perkins, DL; Garcia, JG; Yuan, JXJ; Zhang, W Fenfluramine-induced gene dysregulation in human pulmonary artery smooth muscle and endothelial cells. Pulm Circ, 1(3), 405-18. 2011.
PMID: 22140631.
PMCID: PMC3224433.
Zhang, Y; Noth, I; Garcia, JGN; Kaminski, N A variant in the promoter of MUC5B and idiopathic pulmonary fibrosis. N Engl J Med, 364(16), 1576-7. 2011.
PMID: 21506748.
PMCID: PMC4327944.
Zhao, Y; Gorshkova, IA; Berdyshev, E; He, D; Fu, P; Ma, W; Su, Y; Usatyuk, PV; Pendyala, S; Oskouian, B; Saba, JD; Garcia, JGN; Natarajan, V Protection of LPS-induced murine acute lung injury by sphingosine-1-phosphate lyase suppression. Am J Respir Cell Mol Biol, 45(2), 426-35. 2011.
PMID: 21148740.
PMCID: PMC3175568.

2010 - 2006

Beiser, DG; Wang, H; Li, J; Wang, X; Yordanova, V; Das, A; Mirzapoiazova, T; Garcia, JGN; Stern, SA; Hoek, TLVanden Plasma and myocardial visfatin expression changes are associated with therapeutic hypothermia protection during murine hemorrhagic shock/resuscitation. Resuscitation, 81(6), 742-8. 2010.
PMID: 20347206.
PMCID: PMC2963096.
Danilov, SM; Balyasnikova, IV; Danilova, AS; Naperova, IA; Arablinskaya, NE; Borisov, SE; Metzger, R; Franke, FE; Schwartz, DE; Gachok, IV; Trakht, IN; Kost, OA; Garcia, JGN Conformational fingerprinting of the angiotensin I-converting enzyme (ACE). 1. Application in sarcoidosis. J Proteome Res, 9(11), 5782-93. 2010.
PMID: 20873814
Dudek, SM; Chiang, ET; Camp, SM; Guo, Y; Zhao, J; Brown, ME; Singleton, PA; Wang, L; Desai, A; Arce, FT; Lal, R; Van Eyk, JE; Imam, SZ; Garcia, JGN Abl tyrosine kinase phosphorylates nonmuscle Myosin light chain kinase to regulate endothelial barrier function. Mol Biol Cell, 21(22), 4042-56. 2010.
PMID: 20861316.
PMCID: PMC2982111.
Jacob, A; Hack, B; Chiang, E; Garcia, JGN; Quigg, RJ; Alexander, JJ C5a alters blood-brain barrier integrity in experimental lupus. FASEB J, 24(6), 1682-8. 2010.
PMID: 20065106.
PMCID: PMC2874478.
Mambetsariev, N; Mirzapoiazova, T; Mambetsariev, B; Sammani, S; Lennon, FE; Garcia, JGN; Singleton, PA Hyaluronic Acid binding protein 2 is a novel regulator of vascular integrity. Arterioscler Thromb Vasc Biol, 30(3), 483-90. 2010.
PMID: 20042707.
PMCID: PMC2825278.
Peng, Xqi; Damarla, M; Skirball, J; Nonas, S; Wang, Xying; Han, EJ; Hasan, EJ; Cao, X; Boueiz, A; Damico, R; Tuder, RM; Sciuto, AM; Anderson, DR; Garcia, JGN; Kass, DA; Hassoun, PM; Zhang, Jtian Protective role of PI3-kinase/Akt/eNOS signaling in mechanical stress through inhibition of p38 mitogen-activated protein kinase in mouse lung. Acta Pharmacol Sin, 31(2), 175-83. 2010.
PMID: 20139900.
PMCID: PMC4002838.
Sammani, S; Moreno-Vinasco, L; Mirzapoiazova, T; Singleton, PA; Chiang, ET; Evenoski, CL; Wang, T; Mathew, B; Husain, A; Moitra, J; Sun, X; Nunez, L; Jacobson, JR; Dudek, SM; Natarajan, V; Garcia, JGN Differential effects of sphingosine 1-phosphate receptors on airway and vascular barrier function in the murine lung. Am J Respir Cell Mol Biol, 43(4), 394-402. 2010.
PMID: 19749179.
PMCID: PMC2951871.
Shah, CV; Lanken, PN; Localio, R; Gallop, R; Bellamy, S; Ma, SF; Flores, C; Kahn, JM; Finkel, B; Fuchs, BD; Garcia, JGN; Christie, JD An alternative method of acute lung injury classification for use in observational studies. Chest, 138(5), 1054-61. 2010.
PMID: 20576730.
PMCID: PMC2972624.
Singleton, PA; Mirzapoiazova, T; Guo, Y; Sammani, S; Mambetsariev, N; Lennon, FE; Moreno-Vinasco, L; Garcia, JGN High-molecular-weight hyaluronan is a novel inhibitor of pulmonary vascular leakiness. Am J Physiol Lung Cell Mol Physiol, 299(5), L639-51. 2010.
PMID: 20709728.
PMCID: PMC2980391.
Singleton, PA; Mambetsariev, N; Lennon, FE; Mathew, B; Siegler, JH; Moreno-Vinasco, L; Salgia, R; Moss, J; Garcia, JGn Methylnaltrexone potentiates the anti-angiogenic effects of mTOR inhibitors. J Angiogenes Res, 2(1), 5. 2010.
PMID: 20298531
PMCID: PMC2831839.
Sun, X; Ma, SF; Wade, MS; Flores, C; Pino-Yanes, M; Moitra, J; Ober, C; Kittles, R; Husain, AN; Ford, JG; Garcia, JGN Functional variants of the sphingosine-1-phosphate receptor 1 gene associate with asthma susceptibility. J Allergy Clin Immunol, 126(2), 241-9, 249.e1-3. 2010.
PMID: 20624651.
PMCID: PMC3495167.
Sweiss, NJ; Patterson, K; Sawaqed, R; Jabbar, U; Korsten, P; Hogarth, K; Wollman, R; Garcia, JGN; Niewold, TB; Baughman, RP Rheumatologic manifestations of sarcoidosis. Semin Respir Crit Care Med, 31(4), 463-73. 2010.
PMID: 20665396.
PMCID: PMC3314339.
Wang, T; Chiang, ET; Moreno-Vinasco, L; Lang, GD; Pendyala, S; Samet, JM; Geyh, AS; Breysse, PN; Chillrud, SN; Natarajan, V; Garcia, JGN Particulate matter disrupts human lung endothelial barrier integrity via ROS- and p38 MAPK-dependent pathways. Am J Respir Cell Mol Biol, 42(4), 442-9. 2010.
PMID: 19520919.
PMCID: PMC2848737.
Ware, LB; Koyama, T; Billheimer, D; Wu, W; Bernard, GR; Thompson, T; Brower, RG; Standiford, TJ; Martin, TR; Matthay, MA Prognostic and pathogenetic value of combining clinical and biochemical indices in patients with acute lung injury. Chest, 137(2), 288-96. 2010.
PMID: 19858233.
PMCID: PMC2816641.
Berdyshev, EV; Gorshkova, I; Skobeleva, A; Bittman, R; Lu, X; Dudek, SM; Mirzapoiazova, T; Garcia, JGN; Natarajan, V FTY720 inhibits ceramide synthases and up-regulates dihydrosphingosine 1-phosphate formation in human lung endothelial cells. J Biol Chem, 284(9), 5467-77. 2009.
PMID: 19119142.
PMCID: PMC2645812.
Calfee, CS; Eisner, MD; Parsons, PE; Thompson, T; Conner, ER; Matthay, MA; Ware, LB Soluble intercellular adhesion molecule-1 and clinical outcomes in patients with acute lung injury. Intensive Care Med, 35(2), 248-57. 2009.
PMID: 18670758.
PMCID: PMC2790376.
Camp, SM; Bittman, R; Chiang, ET; Moreno-Vinasco, L; Mirzapoiazova, T; Sammani, S; Lu, X; Sun, C; Harbeck, M; Roe, M; Natarajan, V; Garcia, JGN; Dudek, SM Synthetic analogs of FTY720 [2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol] differentially regulate pulmonary vascular permeability in vivo and in vitro. J Pharmacol Exp Ther, 331(1), 54-64. 2009.
PMID: 19592667.
PMCID: PMC2766218.
Chen, B; Yates, E; Huang, Y; Kogut, P; Ma, L; Turner, JR; Tao, Y; Camoretti-Mercado, B; Lang, D; Svensson, EC; Garcia, JGN; Gruber, PJ; Morrisey, EE; Solway, J Alternative promoter and GATA5 transcripts in mouse. Am J Physiol Gastrointest Liver Physiol, 297(6), G1214-22. 2009.
PMID: 19779014.
PMCID: PMC2850090.
Erickson, SE; Shlipak, MG; Martin, GS; Wheeler, AP; Ancukiewicz, M; Matthay, MA; Eisner, MD Racial and ethnic disparities in mortality from acute lung injury. Crit Care Med, 37(1), 1-6. 2009.
PMID: 19050621.
PMCID: PMC2696263.
Finigan, JH; Boueiz, A; Wilkinson, E; Damico, R; Skirball, J; Pae, HHae; Damarla, M; Hasan, E; Pearse, DB; Reddy, SP; Grigoryev, DN; Cheadle, C; Esmon, CT; Garcia, JGN; Hassoun, PM Activated protein C protects against ventilator-induced pulmonary capillary leak. Am J Physiol Lung Cell Mol Physiol, 296(6), L1002-11. 2009.
PMID: 19363121.
PMCID: PMC2692806.
Flores, C; Pérez-Méndez, L; Maca-Meyer, N; Muriel, A; Espinosa, E; Blanco, J; Sangüesa, R; Muros, M; Garcia, JGN; Villar, J A common haplotype of the LBP gene predisposes to severe sepsis. Crit Care Med, 37(10), 2759-66. 2009.
PMID: 19707138
Fu, P; Birukova, AA; Xing, J; Sammani, S; Murley, JS; Garcia, JGN; Grdina, DJ; Birukov, KG Amifostine reduces lung vascular permeability via suppression of inflammatory signalling. Eur Respir J, 33(3), 612-24. 2009.
PMID: 19010997.
PMCID: PMC3661204.
Kolozsvári, B; Szíjgyártó, Z; Bai, P; Gergely, P; Verin, A; Garcia, JGN; Bakó, E Role of calcineurin in thrombin-mediated endothelial cell contraction. Cytometry A, 75(5), 405-11. 2009.
PMID: 19235203.
PMCID: PMC3884896.
Krishnaswamy, S; Kanteti, R; Duke-Cohan, JS; Loganathan, S; Liu, W; Ma, PC; Sattler, M; Singleton, PA; Ramnath, N; Innocenti, F; Nicolae, DL; Ouyang, Z; Liang, J; Minna, J; Kozloff, MF; Ferguson, MK; Natarajan, V; Wang, YC; Garcia, JGN; Vokes, EE; Salgia, R Ethnic differences and functional analysis of MET mutations in lung cancer. Clin Cancer Res, 15(18), 5714-23. 2009.
PMID: 19723643.
PMCID: PMC2767337.
Liu, P; Li, H; Cepeda, J; Zhang, LQin; Cui, X; Garcia, JGN; Ye, SQing Critical role of PBEF expression in pulmonary cell inflammation and permeability. Cell Biol Int, 33(1), 19-30. 2009.
PMID: 18996492.
PMCID: PMC3732657.
Meyer, NJ; Huang, Y; Singleton, PA; Sammani, S; Moitra, J; Evenoski, CL; Husain, AN; Mitra, S; Moreno-Vinasco, L; Jacobson, JR; Lussier, YA; Garcia, JGN GADD45a is a novel candidate gene in inflammatory lung injury via influences on Akt signaling. FASEB J, 23(5), 1325-37. 2009.
PMID: 19124556.
PMCID: PMC2669422.
Pendyala, S; Usatyuk, PV; Gorshkova, IA; Garcia, JGN; Natarajan, V Regulation of NADPH oxidase in vascular endothelium: the role of phospholipases, protein kinases, and cytoskeletal proteins. Antioxid Redox Signal, 11(4), 841-60. 2009.
PMID: 18828698.
PMCID: PMC2850292.
Singleton, PA; Chatchavalvanich, S; Fu, P; Xing, J; Birukova, AA; Fortune, JA; Klibanov, AM; Garcia, JGN; Birukov, KG Akt-mediated transactivation of the S1P1 receptor in caveolin-enriched microdomains regulates endothelial barrier enhancement by oxidized phospholipids. Circ Res, 104(8), 978-86. 2009.
PMID: 19286607.
PMCID: PMC3163385.
Sun, X; Shikata, Y; Wang, L; Ohmori, K; Watanabe, N; Wada, J; Shikata, K; Birukov, KG; Makino, H; Jacobson, JR; Dudek, SM; Garcia, JGN Enhanced interaction between focal adhesion and adherens junction proteins: involvement in sphingosine 1-phosphate-induced endothelial barrier enhancement. Microvasc Res, 77(3), 304-13. 2009.
PMID: 19323978.
PMCID: PMC3136042.
Wadgaonkar, R; Patel, V; Grinkina, N; Romano, C; Liu, J; Zhao, Y; Sammani, S; Garcia, JGN; Natarajan, V Differential regulation of sphingosine kinases 1 and 2 in lung injury. Am J Physiol Lung Cell Mol Physiol, 296(4), L603-13. 2009.
PMID: 19168577.
PMCID: PMC2670763.
Zhao, Y; Usatyuk, PV; Gorshkova, IA; He, D; Wang, T; Moreno-Vinasco, L; Geyh, AS; Breysse, PN; Samet, JM; Spannhake, EWm; Garcia, JGN; Natarajan, V Regulation of COX-2 expression and IL-6 release by particulate matter in airway epithelial cells. Am J Respir Cell Mol Biol, 40(1), 19-30. 2009.
PMID: 18617679.
PMCID: PMC5459547.
Arce, FTerán; Whitlock, JL; Birukova, AA; Birukov, KG; Arnsdorf, MF; Lal, R; Garcia, JGN; Dudek, SM Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin. Biophys J, 95(2), 886-94. 2008.
PMID: 18408039.
PMCID: PMC2440433.
Archer, SL; Gomberg-Maitland, M; Maitland, ML; Rich, S; Garcia, JGN; Weir, K Mitochondrial metabolism, redox signaling, and fusion: a mitochondria-ROS-HIF-1alpha-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer. Am J Physiol Heart Circ Physiol, 294(2), H570-8. 2008.
PMID: 18083891.
Cai, H; Liu, D; Garcia, JGN CaM Kinase II-dependent pathophysiological signalling in endothelial cells. Cardiovasc Res, 77(1), 30-4. 2008.
PMID: 18006482.
Chen, W; Pendyala, S; Natarajan, V; Garcia, JGN; Jacobson, JR Endothelial cell barrier protection by simvastatin: GTPase regulation and NADPH oxidase inhibition. Am J Physiol Lung Cell Mol Physiol, 295(4), L575-83. 2008.
PMID: 18658277.
PMCID: PMC2575942.
Christie, JD; Ma, SF; Aplenc, R; Li, M; Lanken, PN; Shah, CV; Fuchs, B; Albelda, SM; Flores, C; Garcia, JGN Variation in the myosin light chain kinase gene is associated with development of acute lung injury after major trauma. Crit Care Med, 36(10), 2794-800. 2008.
PMID: 18828194.
Damico, RL; Chesley, A; Johnston, L; Bind, EP; Amaro, E; Nijmeh, J; Karakas, B; Welsh, L; Pearse, DB; Garcia, JGN; Crow, MT Macrophage migration inhibitory factor governs endothelial cell sensitivity to LPS-induced apoptosis. Am J Respir Cell Mol Biol, 39(1), 77-85. 2008.
PMID: 18239193.
PMCID: PMC2438450.
Flores, C; Ma, SF; Maresso, K; Wade, MS; Villar, J; Garcia, JGN IL6 gene-wide haplotype is associated with susceptibility to acute lung injury. Transl Res, 152(1), 11-7. 2008.
PMID: 18593632.
Gorshkova, I; He, D; Berdyshev, E; Usatuyk, P; Burns, M; Kalari, S; Zhao, Y; Pendyala, S; Garcia, JGN; Pyne, NJ; Brindley, DN; Natarajan, V Protein kinase C-epsilon regulates sphingosine 1-phosphate-mediated migration of human lung endothelial cells through activation of phospholipase D2, protein kinase C-zeta, and Rac1. J Biol Chem, 283(17), 11794-806. 2008.
PMID: 18296444.
PMCID: PMC2431079.
Grigoryev, DN; Mathai, SC; Fisher, MR; Girgis, RE; Zaiman, AL; Housten-Harris, T; Cheadle, C; Gao, L; Hummers, LK; Champion, HC; Garcia, JGN; Wigley, FM; Tuder, RM; Barnes, KC; Hassoun, PM Identification of candidate genes in scleroderma-related pulmonary arterial hypertension. Transl Res, 151(4), 197-207. 2008.
PMID: 18355767.
PMCID: PMC2359723.
Hong, SB; Huang, Y; Moreno-Vinasco, L; Sammani, S; Moitra, J; Barnard, JW; Ma, SF; Mirzapoiazova, T; Evenoski, C; Reeves, RR; Chiang, ET; Lang, GD; Husain, AN; Dudek, SM; Jacobson, JR; Ye, SQ; Lussier, YA; Garcia, JGN Essential role of pre-B-cell colony enhancing factor in ventilator-induced lung injury. Am J Respir Crit Care Med, 178(6), 605-17. 2008.
PMID: 18658108.
PMCID: PMC2542434.
Kolosova, IA; Mirzapoiazova, T; Moreno-Vinasco, L; Sammani, S; Garcia, JGN; Verin, AD Protective effect of purinergic agonist ATPgammaS against acute lung injury. Am J Physiol Lung Cell Mol Physiol, 294(2), L319-24. 2008.
PMID: 17993588.
Ma, SF; Flores, C; Wade, MS; Dudek, SM; Nicolae, DL; Ober, C; Garcia, JGN A common cortactin gene variation confers differential susceptibility to severe asthma. Genet Epidemiol, 32(8), 757-66. 2008.
PMID: 18521921.
PMCID: PMC3774307.
Moreno-Vinasco, L; Jacobson, JR; Bonde, P; Sammani, S; Mirzapoiazova, T; Vigneswaran, WT; Garcia, JG Attenuation of rodent lung ischemia-reperfusion injury by sphingosine 1-phosphate. Journal of Organ Dysfunction, 4(2), 106 - 114. 2008.
Moreno-Vinasco, L; Gomberg-Maitland, M; Maitland, ML; Desai, AA; Singleton, PA; Sammani, S; Sam, L; Liu, Y; Husain, AN; Lang, RM; Ratain, MJ; Lussier, YA; Garcia, JGN Genomic assessment of a multikinase inhibitor, sorafenib, in a rodent model of pulmonary hypertension. Physiol Genomics, 33(2), 278-91. 2008.
PMID: 18303084.
PMCID: PMC3616402.
Neptune, ER; Podowski, M; Calvi, C; Cho, JH; Garcia, JGN; Tuder, R; Linnoila, I; Tsai, MJ; Dietz, HC Targeted disruption of NeuroD, a proneural basic helix-loop-helix factor, impairs distal lung formation and neuroendocrine morphology in the neonatal lung. J Biol Chem, 283(30), 21160-9. 2008.
PMID: 18339630.
PMCID: PMC2475704.
Nonas, S; Birukova, AA; Fu, P; Xing, J; Chatchavalvanich, S; Bochkov, VN; Leitinger, N; Garcia, JGN; Birukov, KG Oxidized phospholipids reduce ventilator-induced vascular leak and inflammation in vivo. Crit Care, 12(1), R27. 2008.
PMID: 18304335.
PMCID: PMC2374596.
Szczepaniak, WS; Zhang, Y; Hagerty, S; Crow, MT; Kesari, P; Garcia, JGN; Choi, AMK; Simon, BA; McVerry, BJ Sphingosine 1-phosphate rescues canine LPS-induced acute lung injury and alters systemic inflammatory cytokine production in vivo. Transl Res, 152(5), 213-24. 2008.
PMID: 19010292.
PMCID: PMC2605585.
Wang, T; Moreno-Vinasco, L; Huang, Y; Lang, GD; Linares, JD; Goonewardena, SN; Grabavoy, A; Samet, JM; Geyh, AS; Breysse, PN; Lussier, YA; Natarajan, V; Garcia, JGN Murine lung responses to ambient particulate matter: genomic analysis and influence on airway hyperresponsiveness. Environ Health Perspect, 116(11), 1500-8. 2008.
PMID: 19057703.
PMCID: PMC2592270.
Wurfel, MM; Gordon, AC; Holden, TD; Radella, F; Strout, J; Kajikawa, O; Ruzinski, JT; Rona, G; Black, A; Stratton, S; Jarvik, GP; Hajjar, AM; Nickerson, DA; Rieder, M; Sevransky, J; Maloney, JP; Moss, M; Martin, G; Shanholtz, C; Garcia, JGN; Gao, L; Brower, R; Barnes, KC; Walley, KR; Russell, JA; Martin, TR Toll-like receptor 1 polymorphisms affect innate immune responses and outcomes in sepsis. Am J Respir Crit Care Med, 178(7), 710-20. 2008.
PMID: 18635889.
PMCID: PMC2556453.
Zhang, LQin; Adyshev, DM; Singleton, P; Li, H; Cepeda, J; Huang, SY; Zou, X; Verin, AD; Tu, J; Garcia, JGN; Ye, SQing Interactions between PBEF and oxidative stress proteins--a potential new mechanism underlying PBEF in the pathogenesis of acute lung injury. FEBS Lett, 582(13), 1802-8. 2008.
PMID: 18486613.
PMCID: PMC2519886.
Zhang, LQin; Ma, SF; Grigoryev, D; Lavoie, TL; Xiao, HQing; Setterquist, R; Li, H; Jacobson, J; Garcia, JGN; Ye, SQing Temporal gene expression analysis of human coronary artery endothelial cells treated with Simvastatin. Gene Expr, 14(4), 229-39. 2008.
PMID: 19110722.
Dudek, SM; Camp, SM; Chiang, ET; Singleton, PA; Usatyuk, PV; Zhao, Y; Natarajan, V; Garcia, JGN Pulmonary endothelial cell barrier enhancement by FTY720 does not require the S1P1 receptor. Cell Signal, 19(8), 1754-64. 2007.
PMID: 17475445.
PMCID: PMC2682440.
Flores, C; Ma, SF; Maresso, K; Ober, C; Garcia, JGN A variant of the myosin light chain kinase gene is associated with severe asthma in African Americans. Genet Epidemiol, 31(4), 296-305. 2007.
PMID: 17266121.
Gao, L; Flores, C; Fan-Ma, S; Miller, EJ; Moitra, J; Moreno, L; Wadgaonkar, R; Simon, B; Brower, R; Sevransky, J; Tuder, RM; Maloney, JP; Moss, M; Shanholtz, C; Yates, R; Meduri, GUmberto; Ye, SQ; Barnes, KC; Garcia, JGN Macrophage migration inhibitory factor in acute lung injury: expression, biomarker, and associations. Transl Res, 150(1), 18-29. 2007.
PMID: 17585860.
PMCID: PMC1989118.
Gao, L; Grant, AV; Rafaels, N; Stockton-Porter, M; Watkins, T; Gao, P; Chi, P; Muñoz, M; Watson, H; Dunston, G; Togias, A; Hansel, N; Sevransky, J; Maloney, JP; Moss, M; Shanholtz, C; Brower, R; Garcia, JGN; Grigoryev, DN; Cheadle, C; Beaty, TH; Mathias, RA; Barnes, KC Polymorphisms in the myosin light chain kinase gene that confer risk of severe sepsis are associated with a lower risk of asthma. J Allergy Clin Immunol, 119(5), 1111-8. 2007.
PMID: 17472811.
Hooper, C; Mensah, GA; Haworth, SG; Black, SM; Garcia, JGN; Langleben, D Vascular endothelium summary statement V: Pulmonary hypertension and acute lung injury: public health implications. Vascul Pharmacol, 46(5), 327-9. 2007.
PMID: 17197249
Jacobson, JR; Garcia, JGN Novel therapies for microvascular permeability in sepsis. Curr Drug Targets, 8(4), 509-14. 2007.
PMID: 17430121
Meyer, NJ; Garcia, JGN Wading into the genomic pool to unravel acute lung injury genetics. Proc Am Thorac Soc, 4(1), 69-76. 2007.
PMID: 17202294.
Mirzapoiazova, T; Kolosova, IA; Moreno, L; Sammani, S; Garcia, JGN; Verin, AD Suppression of endotoxin-induced inflammation by taxol. Eur Respir J, 30(3), 429-35. 2007.
PMID: 17537765.
Nonas, SA; Moreno-Vinasco, L; Vinasco, LMoreno; Ma, SFan; Jacobson, JR; Desai, AA; Dudek, SM; Flores, C; Hassoun, PM; Sam, L; Ye, SQ; Moitra, J; Barnard, J; Grigoryev, DN; Lussier, YA; Garcia, JGN Use of consomic rats for genomic insights into ventilator-associated lung injury. Am J Physiol Lung Cell Mol Physiol, 293(2), L292-302. 2007.
PMID: 17468131.
PMCID: PMC3616407.
Papaiahgari, S; Yerrapureddy, A; Hassoun, PM; Garcia, JGN; Birukov, KG; Reddy, SP EGFR-activated signaling and actin remodeling regulate cyclic stretch-induced NRF2-ARE activation. Am J Respir Cell Mol Biol, 36(3), 304-12. 2007.
PMID: 17008637.
PMCID: PMC1899320.
Singleton, PA; Moreno-Vinasco, L; Sammani, S; Wanderling, SL; Moss, J; Garcia, JGN Attenuation of vascular permeability by methylnaltrexone: role of mOP-R and S1P3 transactivation. Am J Respir Cell Mol Biol, 37(2), 222-31. 2007.
PMID: 17395891
Singleton, PA; Salgia, R; Moreno-Vinasco, L; Moitra, J; Sammani, S; Mirzapoiazova, T; Garcia, JGN CD44 regulates hepatocyte growth factor-mediated vascular integrity. Role of c-Met, Tiam1/Rac1, dynamin 2, and cortactin. J Biol Chem, 282(42), 30643-57. 2007.
PMID: 17702746.
Usatyuk, PV; Romer, LH; He, D; Parinandi, NL; Kleinberg, ME; Zhan, S; Jacobson, JR; Dudek, SM; Pendyala, S; Garcia, JGN; Natarajan, V Regulation of hyperoxia-induced NADPH oxidase activation in human lung endothelial cells by the actin cytoskeleton and cortactin. J Biol Chem, 282(32), 23284-95. 2007.
PMID: 17562703.
Zhao, Y; Kalari, SK; Usatyuk, PV; Gorshkova, I; He, D; Watkins, T; Brindley, DN; Sun, C; Bittman, R; Garcia, JGN; Berdyshev, EV; Natarajan, V Intracellular generation of sphingosine 1-phosphate in human lung endothelial cells: role of lipid phosphate phosphatase-1 and sphingosine kinase 1. J Biol Chem, 282(19), 14165-77. 2007.
PMID: 17379599.
PMCID: PMC2659598.
Abdulnour, REE; Peng, X; Finigan, JH; Han, EJ; Hasan, EJ; Birukov, KG; Reddy, SP; Watkins, JE; Kayyali, US; Garcia, JGN; Tuder, RM; Hassoun, PM Mechanical stress activates xanthine oxidoreductase through MAP kinase-dependent pathways. Am J Physiol Lung Cell Mol Physiol, 291(3), L345-53. 2006.
PMID: 16632522.
Barnes, KC; Grant, A; Gao, P; Baltadjieva, D; Berg, T; Chi, P; Zhang, S; Zambelli-Weiner, A; Ehrlich, E; Zardkoohi, O; Brummet, ME; Stockton, M; Watkins, T; Gao, L; Gittens, M; Wills-Karp, M; Cheadle, C; Beck, LA; Beaty, TH; Becker, KG; Garcia, JGN; Mathias, RA Polymorphisms in the novel gene acyloxyacyl hydroxylase (AOAH) are associated with asthma and associated phenotypes. J Allergy Clin Immunol, 118(1), 70-7. 2006.
PMID: 16815140.
Barnes, KC; Grant, AV; Baltadzhieva, D; Zhang, S; Berg, T; Shao, L; Zambelli-Weiner, A; Anderson, W; Nelsen, A; Pillai, S; Yarnall, DP; Dienger, K; Ingersoll, RG; Scott, AF; Fallin, MD; Mathias, RA; Beaty, TH; Garcia, JGN; Wills-Karp, M Variants in the gene encoding C3 are associated with asthma and related phenotypes among African Caribbean families. Genes Immun, 7(1), 27-35. 2006.
PMID: 16355111.
Birukova, AA; Chatchavalvanich, S; Rios, A; Kawkitinarong, K; Garcia, JGN; Birukov, KG Differential regulation of pulmonary endothelial monolayer integrity by varying degrees of cyclic stretch. Am J Pathol, 168(5), 1749-61. 2006.
PMID: 16651639.
PMCID: PMC1606576.
Bogatcheva, NV; Birukova, A; Borbiev, T; Kolosova, I; Liu, F; Garcia, JGN; Verin, AD Caldesmon is a cytoskeletal target for PKC in endothelium. J Cell Biochem, 99(6), 1593-605. 2006.
PMID: 16823797.
Bogatcheva, NV; Wang, P; Birukova, AA; Verin, AD; Garcia, JGN Mechanism of fluoride-induced MAP kinase activation in pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol, 290(6), L1139-45. 2006.
PMID: 16414982.
Chi, PB; Duggal, P; Kao, WHLinda; Mathias, RA; Grant, AV; Stockton, ML; Garcia, JGN; Ingersoll, RG; Scott, AF; Beaty, TH; Barnes, KC; Fallin, D Comparison of SNP tagging methods using empirical data: association study of 713 SNPs on chromosome 12q14.3-12q24.21 for asthma and total serum IgE in an African Caribbean population. Genet Epidemiol, 30(7), 609-19. 2006.
PMID: 16830339.
Chiang, ET; Persaud-Sawin, DA; Kulkarni, S; Garcia, JGN; Imani, F Bluetongue virus and double-stranded RNA increase human vascular permeability: role of p38 MAPK. J Clin Immunol, 26(4), 406-16. 2006.
PMID: 16786433
Flores, C; Ma, SF; Maresso, K; Ahmed, O; Garcia, JGN Genomics of acute lung injury. Semin Respir Crit Care Med, 27(4), 389-95. 2006.
PMID: 16909372.
Gao, L; Grant, A; Halder, I; Brower, R; Sevransky, J; Maloney, JP; Moss, M; Shanholtz, C; Yates, CR; Meduri, GUmberto; Shriver, MD; Ingersoll, R; Scott, AF; Beaty, TH; Moitra, J; Ma, SFan; Ye, SQ; Barnes, KC; Garcia, JGN Novel polymorphisms in the myosin light chain kinase gene confer risk for acute lung injury. Am J Respir Cell Mol Biol, 34(4), 487-95. 2006.
PMID: 16399953.
PMCID: PMC2644210.
Garcia, JGN; Vinasco, LMoreno Genomic insights into acute inflammatory lung injury. Am J Physiol Lung Cell Mol Physiol, 291(6), L1113-7. 2006.
PMID: 16877634
Jacobson, JR; Dudek, SM; Singleton, PA; Kolosova, IA; Verin, AD; Garcia, JGN Endothelial cell barrier enhancement by ATP is mediated by the small GTPase Rac and cortactin. Am J Physiol Lung Cell Mol Physiol, 291(2), L289-95. 2006.
PMID: 16825658.
Nonas, S; Miller, I; Kawkitinarong, K; Chatchavalvanich, S; Gorshkova, I; Bochkov, VN; Leitinger, N; Natarajan, V; Garcia, JGN; Birukov, KG Oxidized phospholipids reduce vascular leak and inflammation in rat model of acute lung injury. Am J Respir Crit Care Med, 173(10), 1130-8. 2006.
PMID: 16514111.
PMCID: PMC2662943.
Romer, LH; Birukov, KG; Garcia, JGN Focal adhesions: paradigm for a signaling nexus. Circ Res, 98(5), 606-16. 2006.
PMID: 16543511.
Simon, BA; Easley, B; Grigoryev, DN; Ma, SF; Ye, SQ; Lavoie, T; Tuder, RM; Garcia, JGN Microarray analysis of regional cellular responses to local mechanical stress in acute lung injury. Am J Physiol Lung Cell Mol Physiol, 291(5), L851-61. 2006.
PMID: 16782753.
Singleton, PA; Lingen, MW; Fekete, MJ; Garcia, JGN; Moss, J Methylnaltrexone inhibits opiate and VEGF-induced angiogenesis: role of receptor transactivation. Microvasc Res, 72(1-2), 3-11. 2006.
PMID: 16820176.
Tar, K; Csortos, C; Czikora, I; Olah, G; Ma, SF; Wadgaonkar, R; Gergely, P; Garcia, JGN; Verin, AD Role of protein phosphatase 2A in the regulation of endothelial cell cytoskeleton structure. J Cell Biochem, 98(4), 931-53. 2006.
PMID: 16475161.
West, EE; Lavoie, TL; Orens, JB; Chen, ES; Ye, SQ; Finkelman, FD; Garcia, JGN; McDyer, JF Pluripotent allospecific CD8+ effector T cells traffic to lung in murine obliterative airway disease. Am J Respir Cell Mol Biol, 34(1), 108-18. 2006.
PMID: 16195540.
PMCID: PMC2644186.
Wright, JM; Merlo, CA; Reynolds, JB; Zeitlin, PL; Garcia, JGN; Guggino, WB; Boyle, MP Respiratory epithelial gene expression in patients with mild and severe cystic fibrosis lung disease. Am J Respir Cell Mol Biol, 35(3), 327-36. 2006.
PMID: 16614352.
PMCID: PMC2643286.

2005 - 2001

Berdyshev, EV; Gorshkova, IA; Garcia, JGN; Natarajan, V; Hubbard, WC Quantitative analysis of sphingoid base-1-phosphates as bisacetylated derivatives by liquid chromatography-tandem mass spectrometry. Anal Biochem, 339(1), 129-36. 2005.
PMID: 15766719.
Birukova, AA; Birukov, KG; Adyshev, D; Usatyuk, P; Natarajan, V; Garcia, JGN; Verin, AD Involvement of microtubules and Rho pathway in TGF-beta1-induced lung vascular barrier dysfunction. J Cell Physiol, 204(3), 934-47. 2005.
PMID: 15828024.
Birukova, AA; Birukov, KG; Gorshkov, B; Liu, F; Garcia, JGN; Verin, AD MAP kinases in lung endothelial permeability induced by microtubule disassembly. Am J Physiol Lung Cell Mol Physiol, 289(1), L75-84. 2005.
PMID: 15778245.
Fenton, JW; Brezniak, DV; Ofosu, FA; Shen, GX; Jacobson, JR; Garcia, JGN Statins and thrombin. Curr Drug Targets Cardiovasc Haematol Disord, 5(2), 115-20. 2005.
PMID: 15853752
Finigan, JH; Dudek, SM; Singleton, PA; Chiang, ET; Jacobson, JR; Camp, SM; Ye, SQ; Garcia, JGN Activated protein C mediates novel lung endothelial barrier enhancement: role of sphingosine 1-phosphate receptor transactivation. J Biol Chem, 280(17), 17286-93. 2005.
PMID: 15710622
Garcia, JGN; Ma, SF Polymerase chain reaction: a landmark in the history of gene technology. Crit Care Med, 33(12 Suppl), S429-32. 2005.
PMID: 16340413
Garcia, JGN Searching for candidate genes in acute lung injury: SNPs, Chips and PBEF. Trans Am Clin Climatol Assoc, 116 205-19; discussion 220. 2005.
PMID: 16555615
PMCID: PMC1473142.
Girgis, RE; Ma, SF; Ye, S; Grigoryev, DN; Li, D; Hassoun, PM; Tuder, RM; Johns, RA; Garcia, JGN Differential gene expression in chronic hypoxic pulmonary hypertension: effect of simvastatin treatment. Chest, 128(6 Suppl), 579S. 2005.
PMID: 16373842
Guo, Y; Ma, SF; Grigoryev, D; Van Eyk, J; Garcia, JGN 1-DE MS and 2-D LC-MS analysis of the mouse bronchoalveolar lavage proteome. Proteomics, 5(17), 4608-24. 2005.
PMID: 16240291.
Irizarry, RA; Warren, D; Spencer, F; Kim, IF; Biswal, S; Frank, BC; Gabrielson, E; Garcia, JGN; Geoghegan, J; Germino, G; Griffin, C; Hilmer, SC; Hoffman, E; Jedlicka, AE; Kawasaki, E; Martínez-Murillo, F; Morsberger, L; Lee, H; Petersen, D; Quackenbush, J; Scott, A; Wilson, M; Yang, Y; Ye, SQing; Yu, W Multiple-laboratory comparison of microarray platforms. Nat Methods, 2(5), 345-50. 2005.
PMID: 15846361.
Jacobson, JR; Barnard, JW; Grigoryev, DN; Ma, SF; Tuder, RM; Garcia, JGN Simvastatin attenuates vascular leak and inflammation in murine inflammatory lung injury. Am J Physiol Lung Cell Mol Physiol, 288(6), L1026-32. 2005.
PMID: 15665042.
Kittleson, MM; Minhas, KM; Irizarry, RA; Ye, SQ; Edness, G; Breton, E; Conte, JV; Tomaselli, G; Garcia, JGN; Hare, JM Gene expression analysis of ischemic and nonischemic cardiomyopathy: shared and distinct genes in the development of heart failure. Physiol Genomics, 21(3), 299-307. 2005.
PMID: 15769906
Kittleson, MM; Minhas, KM; Irizarry, RA; Ye, SQ; Edness, G; Breton, E; Conte, JV; Tomaselli, G; Garcia, JGN; Hare, JM Gene expression in giant cell myocarditis: Altered expression of immune response genes. Int J Cardiol, 102(2), 333-40. 2005.
PMID: 15982506.
Kolosova, IA; Mirzapoiazova, T; Adyshev, D; Usatyuk, P; Romer, LH; Jacobson, JR; Natarajan, V; Pearse, DB; Garcia, JGN; Verin, AD Signaling pathways involved in adenosine triphosphate-induced endothelial cell barrier enhancement. Circ Res, 97(2), 115-24. 2005.
PMID: 15994434.
Ma, SF; Grigoryev, DN; Taylor, AD; Nonas, S; Sammani, S; Ye, SQing; Garcia, JGN Bioinformatic identification of novel early stress response genes in rodent models of lung injury. Am J Physiol Lung Cell Mol Physiol, 289(3), L468-77. 2005.
PMID: 15908477.
Manalo, DJ; Rowan, A; Lavoie, T; Natarajan, L; Kelly, BD; Ye, SQ; Garcia, JGN; Semenza, GL Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1. Blood, 105(2), 659-69. 2005.
PMID: 15374877.
McGlothlin, JR; Gao, L; Lavoie, T; Simon, BA; Easley, B; Ma, SF; Rumala, BB; Garcia, JGN; Ye, SQing Molecular cloning and characterization of canine pre-B-cell colony-enhancing factor. Biochem Genet, 43(3-4), 127-41. 2005.
PMID: 15934174.
Mirzapoiazova, T; Kolosova, IA; Romer, L; Garcia, JGN; Verin, AD The role of caldesmon in the regulation of endothelial cytoskeleton and migration. J Cell Physiol, 203(3), 520-8. 2005.
PMID: 15521070.
Nakashima, S; Soong, R; Fox-Talbot, K; Qian, Z; Rahimi, S; Wasowska, BA; Rohde, CA; Chen, S; Garcia, JGN; Baldwin, WM Impact of MHC class II incompatibility on localization of mononuclear cell infiltrates to the bronchiolar compartment of orthotopic lung allografts. Am J Transplant, 5(4 Pt 1), 694-701. 2005.
PMID: 15760392.
PMCID: PMC1351097.
Nonas, SA; Finigan, JH; Gao, L; Garcia, JGN Functional genomic insights into acute lung injury: role of ventilators and mechanical stress. Proc Am Thorac Soc, 2(3), 188-94. 2005.
PMID: 16222036
Peng, X; Abdulnour, REE; Sammani, S; Ma, SF; Han, EJ; Hasan, EJ; Tuder, R; Garcia, JGN; Hassoun, PM Inducible nitric oxide synthase contributes to ventilator-induced lung injury. Am J Respir Crit Care Med, 172(4), 470-9. 2005.
PMID: 15937288.
PMCID: PMC2718528.
Varadharaj, S; Watkins, T; Cardounel, AJ; Garcia, JGN; Zweier, JL; Kuppusamy, P; Natarajan, V; Parinandi, NL Vitamin C-induced loss of redox-dependent viability in lung microvascular endothelial cells. Antioxid Redox Signal, 7(1-2), 287-300. 2005.
PMID: 15650416.
Wadgaonkar, R; Linz-McGillem, L; Zaiman, AL; Garcia, JGN Endothelial cell myosin light chain kinase (MLCK) regulates TNFalpha-induced NFkappaB activity. J Cell Biochem, 94(2), 351-64. 2005.
PMID: 15526279
Wadgaonkar, R; Dudek, SM; Zaiman, AL; Linz-McGillem, L; Verin, AD; Nurmukhambetova, S; Romer, LH; Garcia, JGN Intracellular interaction of myosin light chain kinase with macrophage migration inhibition factor (MIF) in endothelium. J Cell Biochem, 95(4), 849-58. 2005.
PMID: 15838879
Ye, SQ; Simon, BA; Maloney, JP; Zambelli-Weiner, A; Gao, L; Grant, A; Easley, B; McVerry, BJ; Tuder, RM; Standiford, T; Brower, RG; Barnes, KC; Garcia, JGN Pre-B-cell colony-enhancing factor as a potential novel biomarker in acute lung injury. Am J Respir Crit Care Med, 171(4), 361-70. 2005.
PMID: 15579727.
Ye, SQ; Zhang, LQ; Adyshev, D; Usatyuk, PV; Garcia, AN; Lavoie, TL; Verin, AD; Natarajan, V; Garcia, JGN Pre-B-cell-colony-enhancing factor is critically involved in thrombin-induced lung endothelial cell barrier dysregulation. Microvasc Res, 70(3), 142-51. 2005.
PMID: 16188281.
Atwood, CW; McCrory, D; Garcia, JGN; Abman, SH; Ahearn, GS Pulmonary artery hypertension and sleep-disordered breathing: ACCP evidence-based clinical practice guidelines. Chest, 126(1 Suppl), 72S-77S. 2004.
PMID: 15249496
Birukov, KG; Bochkov, VN; Birukova, AA; Kawkitinarong, K; Rios, A; Leitner, A; Verin, AD; Bokoch, GM; Leitinger, N; Garcia, JGN Epoxycyclopentenone-containing oxidized phospholipids restore endothelial barrier function via Cdc42 and Rac. Circ Res, 95(9), 892-901. 2004.
PMID: 15472119.
Birukova, AA; Smurova, K; Birukov, KG; Usatyuk, P; Liu, F; Kaibuchi, K; Ricks-Cord, A; Natarajan, V; Alieva, I; Garcia, JGN; Verin, AD Microtubule disassembly induces cytoskeletal remodeling and lung vascular barrier dysfunction: role of Rho-dependent mechanisms. J Cell Physiol, 201(1), 55-70. 2004.
PMID: 15281089.
Birukova, AA; Birukov, KG; Smurova, K; Adyshev, D; Kaibuchi, K; Alieva, I; Garcia, JGN; Verin, AD Novel role of microtubules in thrombin-induced endothelial barrier dysfunction. FASEB J, 18(15), 1879-90. 2004.
PMID: 15576491.
Birukova, AA; Liu, F; Garcia, JGN; Verin, AD Protein kinase A attenuates endothelial cell barrier dysfunction induced by microtubule disassembly. Am J Physiol Lung Cell Mol Physiol, 287(1), L86-93. 2004.
PMID: 15003930.
Birukova, AA; Smurova, K; Birukov, KG; Kaibuchi, K; Garcia, JGN; Verin, AD Role of Rho GTPases in thrombin-induced lung vascular endothelial cells barrier dysfunction. Microvasc Res, 67(1), 64-77. 2004.
PMID: 14709404.
Borbiev, T; Birukova, A; Liu, F; Nurmukhambetova, S; Gerthoffer, WT; Garcia, JGN; Verin, AD p38 MAP kinase-dependent regulation of endothelial cell permeability. Am J Physiol Lung Cell Mol Physiol, 287(5), L911-8. 2004.
PMID: 15475493.
Clayburgh, DR; Rosen, S; Witkowski, ED; Wang, F; Blair, S; Dudek, S; Garcia, JGN; Alverdy, JC; Turner, JR A differentiation-dependent splice variant of myosin light chain kinase, MLCK1, regulates epithelial tight junction permeability. J Biol Chem, 279(53), 55506-13. 2004.
PMID: 15507455.
PMCID: PMC1237105.
Cummings, R; Zhao, Y; Jacoby, D; Spannhake, W; Ohba, M; Garcia, JGN; Watkins, T; He, D; Saatian, B; Natarajan, V Protein kinase Cdelta mediates lysophosphatidic acid-induced NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells. J Biol Chem, 279(39), 41085-94. 2004.
PMID: 15280372.
Dudek, SM; Jacobson, JR; Chiang, ET; Birukov, KG; Wang, P; Zhan, X; Garcia, JGN Pulmonary endothelial cell barrier enhancement by sphingosine 1-phosphate: roles for cortactin and myosin light chain kinase. J Biol Chem, 279(23), 24692-700. 2004.
PMID: 15056655.
Grigoryev, DN; Ma, SF; Irizarry, RA; Ye, SQing; Quackenbush, J; Garcia, JGN Orthologous gene-expression profiling in multi-species models: search for candidate genes. Genome Biol, 5(5), R34. 2004.
PMID: 15128448.
PMCID: PMC416470.
Grigoryev, DN; Finigan, JH; Hassoun, P; Garcia, JGN Science review: searching for gene candidates in acute lung injury. Crit Care, 8(6), 440-7. 2004.
PMID: 15566614
PMCID: PMC1065043.
Jacobson, JR; Dudek, SM; Birukov, KG; Ye, SQ; Grigoryev, DN; Girgis, RE; Garcia, JGN Cytoskeletal activation and altered gene expression in endothelial barrier regulation by simvastatin. Am J Respir Cell Mol Biol, 30(5), 662-70. 2004.
PMID: 14630613.
Kawkitinarong, K; Linz-McGillem, L; Birukov, KG; Garcia, JGN Differential regulation of human lung epithelial and endothelial barrier function by thrombin. Am J Respir Cell Mol Biol, 31(5), 517-27. 2004.
PMID: 15284075.
Kittleson, MM; Ye, SQ; Irizarry, RA; Minhas, KM; Edness, G; Conte, JV; Parmigiani, G; Miller, LW; Chen, Y; Hall, JL; Garcia, JGN; Hare, JM Identification of a gene expression profile that differentiates between ischemic and nonischemic cardiomyopathy. Circulation, 110(22), 3444-51. 2004.
PMID: 15557369.
Kolosova, IA; Ma, SF; Adyshev, DM; Wang, P; Ohba, M; Natarajan, V; Garcia, JGN; Verin, AD Role of CPI-17 in the regulation of endothelial cytoskeleton. Am J Physiol Lung Cell Mol Physiol, 287(5), L970-80. 2004.
PMID: 15234908.
Li, Y; Uruno, T; Haudenschild, C; Dudek, SM; Garcia, JGN; Zhan, X Interaction of cortactin and Arp2/3 complex is required for sphingosine-1-phosphate-induced endothelial cell remodeling. Exp Cell Res, 298(1), 107-21. 2004.
PMID: 15242766.
McVerry, BJ; Garcia, JGN Endothelial cell barrier regulation by sphingosine 1-phosphate. J Cell Biochem, 92(6), 1075-85. 2004.
PMID: 15258893.
McVerry, BJ; Peng, X; Hassoun, PM; Sammani, S; Simon, BA; Garcia, JGN Sphingosine 1-phosphate reduces vascular leak in murine and canine models of acute lung injury. Am J Respir Crit Care Med, 170(9), 987-93. 2004.
PMID: 15282202.
Newman, JH; Fanburg, BL; Archer, SL; Badesch, DB; Barst, RJ; Garcia, JGN; Kao, PN; Knowles, JA; Loyd, JE; McGoon, MD; Morse, JH; Nichols, WC; Rabinovitch, M; Rodman, DM; Stevens, T; Tuder, RM; Voelkel, NF; Gail, DB Pulmonary arterial hypertension: future directions: report of a National Heart, Lung and Blood Institute/Office of Rare Diseases workshop. Circulation, 109(24), 2947-52. 2004.
PMID: 15210611
Peng, X; Hassoun, PM; Sammani, S; McVerry, BJ; Burne, MJ; Rabb, H; Pearse, D; Tuder, RM; Garcia, JGN Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury. Am J Respir Crit Care Med, 169(11), 1245-51. 2004.
PMID: 15020292.
Smurova, KM; Biriukova, AA; Garcia, JG; Vorob'ev, IA; Alieva, IB; Verin, AD [Reorganization of microtubule system in pulmonary endothelial cells in response to thrombin treatment]. Tsitologiia, 46(8), 695-703. 2004.
PMID: 15598015.
Tar, K; Birukova, AA; Csortos, C; Bakó, E; Garcia, JGN; Verin, AD Phosphatase 2A is involved in endothelial cell microtubule remodeling and barrier regulation. J Cell Biochem, 92(3), 534-46. 2004.
PMID: 15156565.
Wadgaonkar, R; Pierce, JW; Somnay, K; Damico, RL; Crow, MT; Collins, T; Garcia, JGN Regulation of c-Jun N-terminal kinase and p38 kinase pathways in endothelial cells. Am J Respir Cell Mol Biol, 31(4), 423-31. 2004.
PMID: 15231489.
Becker, PM; Kazi, AA; Wadgaonkar, R; Pearse, DB; Kwiatkowski, D; Garcia, JGN Pulmonary vascular permeability and ischemic injury in gelsolin-deficient mice. Am J Respir Cell Mol Biol, 28(4), 478-84. 2003.
PMID: 12654637.
Birukov, KG; Jacobson, JR; Flores, AA; Ye, SQ; Birukova, AA; Verin, AD; Garcia, JGN Magnitude-dependent regulation of pulmonary endothelial cell barrier function by cyclic stretch. Am J Physiol Lung Cell Mol Physiol, 285(4), L785-97. 2003.
PMID: 12639843.
Bogatcheva, NV; Dudek, SM; Garcia, JGN; Verin, AD Mitogen-activated protein kinases in endothelial pathophysiology. J Investig Med, 51(6), 341-52. 2003.
PMID: 14686637.
Bogatcheva, NV; Verin, AD; Wang, P; Birukova, AA; Birukov, KG; Mirzopoyazova, T; Adyshev, DM; Chiang, ET; Crow, MT; Garcia, JGN Phorbol esters increase MLC phosphorylation and actin remodeling in bovine lung endothelium without increased contraction. Am J Physiol Lung Cell Mol Physiol, 285(2), L415-26. 2003.
PMID: 12740219.
Borbiev, T; Verin, AD; Birukova, A; Liu, F; Crow, MT; Garcia, JGN Role of CaM kinase II and ERK activation in thrombin-induced endothelial cell barrier dysfunction. Am J Physiol Lung Cell Mol Physiol, 285(1), L43-54. 2003.
PMID: 12788788.
Cappola, TP; Cope, L; Cernetich, A; Barouch, LA; Minhas, K; Irizarry, RA; Parmigiani, G; Durrani, S; Lavoie, T; Hoffman, EP; Ye, SQ; Garcia, JGN; Hare, JM Deficiency of different nitric oxide synthase isoforms activates divergent transcriptional programs in cardiac hypertrophy. Physiol Genomics, 14(1), 25-34. 2003.
PMID: 12709511.
Dull, RO; Dinavahi, R; Schwartz, L; Humphries, DE; Berry, D; Sasisekharan, R; Garcia, JGN Lung endothelial heparan sulfates mediate cationic peptide-induced barrier dysfunction: a new role for the glycocalyx. Am J Physiol Lung Cell Mol Physiol, 285(5), L986-95. 2003.
PMID: 12754183.
Girgis, RE; Li, D; Zhan, X; Garcia, JGN; Tuder, RM; Hassoun, PM; Johns, RA Attenuation of chronic hypoxic pulmonary hypertension by simvastatin. Am J Physiol Heart Circ Physiol, 285(3), H938-45. 2003.
PMID: 12750068
Jacobson, JR; Garcia, JGN Genomics made functional in ventilator-associated lung injury. Am J Respir Crit Care Med, 168(9), 1023-5. 2003.
PMID: 14581285
Parinandi, NL; Kleinberg, MA; Usatyuk, PV; Cummings, RJ; Pennathur, A; Cardounel, AJ; Zweier, JL; Garcia, JGN; Natarajan, V Hyperoxia-induced NAD(P)H oxidase activation and regulation by MAP kinases in human lung endothelial cells. Am J Physiol Lung Cell Mol Physiol, 284(1), L26-38. 2003.
PMID: 12388366.
Peri, S; Navarro, D; Amanchy, R; Kristiansen, TZ; Jonnalagadda, CKiran; Surendranath, V; Niranjan, V; Muthusamy, B; Gandhi, TKB; Gronborg, M; Ibarrola, N; Deshpande, N; Shanker, K; Shivashankar, HN; Rashmi, BP; Ramya, MA; Zhao, Z; Chandrika, KN; Padma, N; Harsha, HC; Yatish, AJ; Kavitha, MP; Menezes, M; Choudhury, DRoy; Suresh, S; Ghosh, N; Saravana, R; Chandran, S; Krishna, S; Joy, M; Anand, SK; Madavan, V; Joseph, A; Wong, GW; Schiemann, WP; Constantinescu, SN; Huang, L; Khosravi-Far, R; Steen, H; Tewari, M; Ghaffari, S; Blobe, GC; Dang, CV; Garcia, JGN; Pevsner, J; Jensen, ON; Roepstorff, P; Deshpande, KS; Chinnaiyan, AM; Hamosh, A; Chakravarti, A; Pandey, A Development of human protein reference database as an initial platform for approaching systems biology in humans. Genome Res, 13(10), 2363-71. 2003.
PMID: 14525934
PMCID: PMC403728.
Petrache, I; Birukov, K; Zaiman, AL; Crow, MT; Deng, H; Wadgaonkar, R; Romer, LH; Garcia, JGN Caspase-dependent cleavage of myosin light chain kinase (MLCK) is involved in TNF-alpha-mediated bovine pulmonary endothelial cell apoptosis. FASEB J, 17(3), 407-16. 2003.
PMID: 12631580.
Petrache, I; Crow, MT; Neuss, M; Garcia, JGN Central involvement of Rho family GTPases in TNF-alpha-mediated bovine pulmonary endothelial cell apoptosis. Biochem Biophys Res Commun, 306(1), 244-9. 2003.
PMID: 12788095.
Petrache, I; Birukova, A; Ramirez, SI; Garcia, JGN; Verin, AD The role of the microtubules in tumor necrosis factor-alpha-induced endothelial cell permeability. Am J Respir Cell Mol Biol, 28(5), 574-81. 2003.
PMID: 12707013.
Schaphorst, KL; Chiang, E; Jacobs, KN; Zaiman, A; Natarajan, V; Wigley, F; Garcia, JGN Role of sphingosine-1 phosphate in the enhancement of endothelial barrier integrity by platelet-released products. Am J Physiol Lung Cell Mol Physiol, 285(1), L258-67. 2003.
PMID: 12626332.
Usatyuk, PV; Fomin, VP; Shi, S; Garcia, JGN; Schaphorst, K; Natarajan, V Role of Ca2+ in diperoxovanadate-induced cytoskeletal remodeling and endothelial cell barrier function. Am J Physiol Lung Cell Mol Physiol, 285(5), L1006-17. 2003.
PMID: 12882766.
Birukov, KG; Birukova, AA; Dudek, SM; Verin, AD; Crow, MT; Zhan, X; DePaola, N; Garcia, JGN Shear stress-mediated cytoskeletal remodeling and cortactin translocation in pulmonary endothelial cells. Am J Respir Cell Mol Biol, 26(4), 453-64. 2002.
PMID: 11919082.
Bogatcheva, NV; Garcia, JGN; Verin, AD Molecular mechanisms of thrombin-induced endothelial cell permeability. Biochemistry (Mosc), 67(1), 75-84. 2002.
PMID: 11841342.
Bogatcheva, NV; Garcia, JGN; Verin, AD Role of tyrosine kinase signaling in endothelial cell barrier regulation. Vascul Pharmacol, 39(4-5), 201-12. 2002.
PMID: 12747960.
Cummings, RJ; Parinandi, NL; Zaiman, A; Wang, L; Usatyuk, PV; Garcia, JGN; Natarajan, V Phospholipase D activation by sphingosine 1-phosphate regulates interleukin-8 secretion in human bronchial epithelial cells. J Biol Chem, 277(33), 30227-35. 2002.
PMID: 12039947.
Dudek, SM; Birukov, KG; Zhan, X; Garcia, JGN Novel interaction of cortactin with endothelial cell myosin light chain kinase. Biochem Biophys Res Commun, 298(4), 511-9. 2002.
PMID: 12408982.
English, D; Brindley, DN; Spiegel, S; Garcia, JGN Lipid mediators of angiogenesis and the signalling pathways they initiate. Biochim Biophys Acta, 1582(1-3), 228-39. 2002.
PMID: 12069833.
Garcia, JGN; Wang, P; Schaphorst, KL; Becker, PM; Borbiev, T; Liu, F; Birukova, A; Jacobs, K; Bogatcheva, N; Verin, AD Critical involvement of p38 MAP kinase in pertussis toxin-induced cytoskeletal reorganization and lung permeability. FASEB J, 16(9), 1064-76. 2002.
PMID: 12087068.
Harvey, K; Welch, Z; Kovala, T; Garcia, JGN; English, D Comparative analysis of in vitro angiogenic activities of endothelial cells of heterogeneous origin. Microvasc Res, 63(3), 316-26. 2002.
PMID: 11969308.
Harvey, K; Siddiqui, RA; Sliva, D; Garcia, JGN; English, D Serum factors involved in human microvascular endothelial cell morphogenesis. J Lab Clin Med, 140(3), 188-98. 2002.
PMID: 12271276
Liu, F; Schaphorst, KL; Verin, AD; Jacobs, K; Birukova, A; Day, RM; Bogatcheva, N; Bottaro, DP; Garcia, JGN Hepatocyte growth factor enhances endothelial cell barrier function and cortical cytoskeletal rearrangement: potential role of glycogen synthase kinase-3beta. FASEB J, 16(9), 950-62. 2002.
PMID: 12087056.
Becker, PM; Verin, AD; Booth, MA; Liu, F; Birukova, A; Garcia, JG Differential regulation of diverse physiological responses to VEGF in pulmonary endothelial cells. Am J Physiol Lung Cell Mol Physiol, 281(6), L1500-11. 2001.
PMID: 11704547.
Birukov, KG; Csortos, C; Marzilli, L; Dudek, S; Ma, SF; Bresnick, AR; Verin, AD; Cotter, RJ; Garcia, JG Differential regulation of alternatively spliced endothelial cell myosin light chain kinase isoforms by p60(Src). J Biol Chem, 276(11), 8567-73. 2001.
PMID: 11113114.
Borbiev, T; Verin, AD; Shi, S; Liu, F; Garcia, JG Regulation of endothelial cell barrier function by calcium/calmodulin-dependent protein kinase II. Am J Physiol Lung Cell Mol Physiol, 280(5), L983-90. 2001.
PMID: 11290523.
Dudek, SM; Garcia, JG Cytoskeletal regulation of pulmonary vascular permeability. J Appl Physiol (1985), 91(4), 1487-500. 2001.
PMID: 11568129.
English, D; Garcia, JG; Brindley, DN Platelet-released phospholipids link haemostasis and angiogenesis. Cardiovasc Res, 49(3), 588-99. 2001.
PMID: 11166272.
Garcia, JG; Wang, P; Liu, F; Hershenson, MB; Borbiev, T; Verin, AD Pertussis toxin directly activates endothelial cell p42/p44 MAP kinases via a novel signaling pathway. Am J Physiol Cell Physiol, 280(5), C1233-41. 2001.
PMID: 11287337.
Garcia, JG; Liu, F; Verin, AD; Birukova, A; Dechert, MA; Gerthoffer, WT; Bamberg, JR; English, D Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement. J Clin Invest, 108(5), 689-701. 2001.
PMID: 11544274.
PMCID: PMC209379.
Liu, F; Verin, AD; Wang, P; Day, R; Wersto, RP; Chrest, FJ; English, DK; Garcia, JG Differential regulation of sphingosine-1-phosphate- and VEGF-induced endothelial cell chemotaxis. Involvement of G(ialpha2)-linked Rho kinase activity. Am J Respir Cell Mol Biol, 24(6), 711-9. 2001.
PMID: 11415936.
Liu, F; Verin, AD; Borbiev, T; Garcia, JG Role of cAMP-dependent protein kinase A activity in endothelial cell cytoskeleton rearrangement. Am J Physiol Lung Cell Mol Physiol, 280(6), L1309-17. 2001.
PMID: 11350812.
Natarajan, V; Scribner, WM; Morris, AJ; Roy, S; Vepa, S; Yang, J; Wadgaonkar, R; Reddy, SP; Garcia, JG; Parinandi, NL Role of p38 MAP kinase in diperoxovanadate-induced phospholipase D activation in endothelial cells. Am J Physiol Lung Cell Mol Physiol, 281(2), L435-49. 2001.
PMID: 11435219.
Parinandi, NL; Roy, S; Shi, S; Cummings, RJ; Morris, AJ; Garcia, JG; Natarajan, V Role of Src kinase in diperoxovanadate-mediated activation of phospholipase D in endothelial cells. Arch Biochem Biophys, 396(2), 231-43. 2001.
PMID: 11747302
Petrache, I; Verin, AD; Crow, MT; Birukova, A; Liu, F; Garcia, JG Differential effect of MLC kinase in TNF-alpha-induced endothelial cell apoptosis and barrier dysfunction. Am J Physiol Lung Cell Mol Physiol, 280(6), L1168-78. 2001.
PMID: 11350795.
Stevens, T; Rosenberg, R; Aird, W; Quertermous, T; Johnson, FL; Garcia, JG; Hebbel, RP; Tuder, RM; Garfinkel, S NHLBI workshop report: endothelial cell phenotypes in heart, lung, and blood diseases. Am J Physiol Cell Physiol, 281(5), C1422-33. 2001.
PMID: 11600404
Verin, AD; Birukova, A; Wang, P; Liu, F; Becker, P; Birukov, K; Garcia, JG Microtubule disassembly increases endothelial cell barrier dysfunction: role of MLC phosphorylation. Am J Physiol Lung Cell Mol Physiol, 281(3), L565-74. 2001.
PMID: 11504682.
Wang, P; Verin, AD; Birukova, A; Gilbert-McClain, LI; Jacobs, K; Garcia, JG Mechanisms of sodium fluoride-induced endothelial cell barrier dysfunction: role of MLC phosphorylation. Am J Physiol Lung Cell Mol Physiol, 281(6), L1472-83. 2001.
PMID: 11704544.

2000 - 1996

Borbiev, T; Nurmukhambetova, S; Liu, F; Verin, AD; Garcia, JG Introduction of C3 exoenzyme into cultured endothelium by lipofectamine. Anal Biochem, 285(2), 260-4. 2000.
PMID: 11017711
Garcia, JG; Schaphorst, KL; Verin, AD; Vepa, S; Patterson, CE; Natarajan, V Diperoxovanadate alters endothelial cell focal contacts and barrier function: role of tyrosine phosphorylation. J Appl Physiol (1985), 89(6), 2333-43. 2000.
PMID: 11090587.
Kovala, AT; Harvey, KA; McGlynn, P; Boguslawski, G; Garcia, JG; English, D High-efficiency transient transfection of endothelial cells for functional analysis. FASEB J, 14(15), 2486-94. 2000.
PMID: 11099466.
Patterson, CE; Lum, H; Schaphorst, KL; Verin, AD; Garcia, JG Regulation of endothelial barrier function by the cAMP-dependent protein kinase. Endothelium, 7(4), 287-308. 2000.
PMID: 11201526.
Shi, S; Garcia, JG; Roy, S; Parinandi, NL; Natarajan, V Involvement of c-Src in diperoxovanadate-induced endothelial cell barrier dysfunction. Am J Physiol Lung Cell Mol Physiol, 279(3), L441-51. 2000.
PMID: 10956618.
Stevens, T; Garcia, JG; Shasby, DM; Bhattacharya, J; Malik, AB Mechanisms regulating endothelial cell barrier function. Am J Physiol Lung Cell Mol Physiol, 279(3), L419-22. 2000.
PMID: 10956614
Verin, AD; Csortos, C; Durbin, SD; Aydanyan, A; Wang, P; Patterson, CE; Garcia, JG Characterization of the protein phosphatase 1 catalytic subunit in endothelium: involvement in contractile responses. J Cell Biochem, 79(1), 113-25. 2000.
PMID: 10906760.
Verin, AD; Liu, F; Bogatcheva, N; Borbiev, T; Hershenson, MB; Wang, P; Garcia, JG Role of ras-dependent ERK activation in phorbol ester-induced endothelial cell barrier dysfunction. Am J Physiol Lung Cell Mol Physiol, 279(2), L360-70. 2000.
PMID: 10926560.
English, D; Cui, Y; Siddiqui, R; Patterson, C; Natarajan, V; Brindley, DN; Garcia, JG Induction of endothelial monolayer permeability by phosphatidate. J Cell Biochem, 75(1), 105-17. 1999.
PMID: 10462709.
Garcia, JG; Verin, AD; Schaphorst, K; Siddiqui, R; Patterson, CE; Csortos, C; Natarajan, V Regulation of endothelial cell myosin light chain kinase by Rho, cortactin, and p60(src). Am J Physiol, 276(6 Pt 1), L989-98. 1999.
PMID: 10362724.
Lazar, V; Garcia, JG A single human myosin light chain kinase gene (MLCK; MYLK). Genomics, 57(2), 256-67. 1999.
PMID: 10198165.
Siddiqui, RA; Akard, LP; Garcia, JG; Cui, Y; English, D Chemotactic migration triggers IL-8 generation in neutrophilic leukocytes. J Immunol, 162(2), 1077-83. 1999.
PMID: 9916736.
Vepa, S; Scribner, WM; Parinandi, NL; English, D; Garcia, JG; Natarajan, V Hydrogen peroxide stimulates tyrosine phosphorylation of focal adhesion kinase in vascular endothelial cells. Am J Physiol, 277(1 Pt 1), L150-8. 1999.
PMID: 10409242.
Garcia, JG; Verin, AD; Herenyiova, M; English, D Adherent neutrophils activate endothelial myosin light chain kinase: role in transendothelial migration. J Appl Physiol (1985), 84(5), 1817-21. 1998.
PMID: 9572834
Gilbert-McClain, LI; Verin, AD; Shi, S; Irwin, RP; Garcia, JG Regulation of endothelial cell myosin light chain phosphorylation and permeability by vanadate. J Cell Biochem, 70(1), 141-55. 1998.
PMID: 9632115.
Hart, CM; Karman, RJ; Blackburn, TL; Gupta, MP; Garcia, JG; Mohler, ER Role of 8-epi PGF2alpha, 8-isoprostane, in H2O2-induced derangements of pulmonary artery endothelial cell barrier function. Prostaglandins Leukot Essent Fatty Acids, 58(1), 9-16. 1998.
PMID: 9482161.
Mannix, ET; Dresser, KS; Aukley, D; Farber, MO; Garcia, JG Cardiopulmonary exercise testing in the evaluation of patients with occupational asthma and reactive airways dysfunction syndrome. J Investig Med, 46(5), 236-42. 1998.
PMID: 9676057
Patterson, CE; Stasek, JE; Bahler, C; Verin, AD; Harrington, MA; Garcia, JG Regulation of interleukin-1-stimulated GMCSF mRNA levels in human endothelium. Endothelium, 6(1), 45-59. 1998.
PMID: 9832332.
Shi, S; Verin, AD; Schaphorst, KL; Gilbert-McClain, LI; Patterson, CE; Irwin, RP; Natarajan, V; Garcia, JG Role of tyrosine phosphorylation in thrombin-induced endothelial cell contraction and barrier function. Endothelium, 6(2), 153-71. 1998.
PMID: 9930649.
Verin, AD; Gilbert-McClain, LI; Patterson, CE; Garcia, JG Biochemical regulation of the nonmuscle myosin light chain kinase isoform in bovine endothelium. Am J Respir Cell Mol Biol, 19(5), 767-76. 1998.
PMID: 9806741.
Verin, AD; Lazar, V; Torry, RJ; Labarrere, CA; Patterson, CE; Garcia, JG Expression of a novel high molecular-weight myosin light chain kinase in endothelium. Am J Respir Cell Mol Biol, 19(5), 758-66. 1998.
PMID: 9806740.
Verin, AD; Cooke, C; Herenyiova, M; Patterson, CE; Garcia, JG Role of Ca2+/calmodulin-dependent phosphatase 2B in thrombin-induced endothelial cell contractile responses. Am J Physiol, 275(4 Pt 1), L788-99. 1998.
PMID: 9755112.
Cui, Y; English, DK; Siddiqui, RA; Heranyiova, M; Garcia, JG Activation of endothelial cell phospholipase D by migrating neutrophils. J Investig Med, 45(6), 388-93. 1997.
PMID: 9291695.
English, D; Martin, M; Harvey, KA; Akard, LP; Allen, R; Widlanski, TS; Garcia, JG; Siddiqui, RA Characterization and purification of neutrophil ecto-phosphatidic acid phosphohydrolase. Biochem J, 324 ( Pt 3) 941-50. 1997.
PMID: 9210420.
PMCID: PMC1218512.
Garcia, JG; Schaphorst, KL; Shi, S; Verin, AD; Hart, CM; Callahan, KS; Patterson, CE Mechanisms of ionomycin-induced endothelial cell barrier dysfunction. Am J Physiol, 273(1 Pt 1), L172-84. 1997.
PMID: 9252554
Garcia, JG; Lazar, V; Gilbert-McClain, LI; Gallagher, PJ; Verin, AD Myosin light chain kinase in endothelium: molecular cloning and regulation. Am J Respir Cell Mol Biol, 16(5), 489-94. 1997.
PMID: 9160829.
Karman, RJ; Garcia, JG; Hart, CM Endothelial cell monolayer dysfunction caused by oxidized low density lipoprotein: attenuation by oleic acid. Prostaglandins Leukot Essent Fatty Acids, 56(5), 345-53. 1997.
PMID: 9175170.
Ma, SF; Garcia, JG; Reuning, U; Little, SP; Bang, NU; Dixon, EP Thrombin induces thrombomodulin mRNA expression via the proteolytically activated thrombin receptor in cultured bovine smooth muscle cells. J Lab Clin Med, 129(6), 611-9. 1997.
PMID: 9178727.
Schaphorst, KL; Pavalko, FM; Patterson, CE; Garcia, JG Thrombin-mediated focal adhesion plaque reorganization in endothelium: role of protein phosphorylation. Am J Respir Cell Mol Biol, 17(4), 443-55. 1997.
PMID: 9376119.
Brashear, A; Unverzagt, FW; Farber, MO; Bonnin, JM; Garcia, JG; Grober, E Ethylene oxide neurotoxicity: a cluster of 12 nurses with peripheral and central nervous system toxicity. Neurology, 46(4), 992-8. 1996.
PMID: 8780078
Cui, Y; Harvey, KA; Siddiqui, RA; Jansen, J; Akard, LP; Thompson, JM; Garcia, JG; English, D Cytosolic inactivation of translocated neutrophil plasma membrane protein tyrosine phosphatase. Blood, 87(1), 341-9. 1996.
PMID: 8547661.
Davis, HW; Crimmins, DL; Thoma, RS; Garcia, JG Phosphorylation of calmodulin in the first calcium-binding pocket by myosin light chain kinase. Arch Biochem Biophys, 332(1), 101-9. 1996.
PMID: 8806714.
Garcia, JG; Verin, AD; Schaphorst, KL Regulation of thrombin-mediated endothelial cell contraction and permeability. Semin Thromb Hemost, 22(4), 309-15. 1996.
PMID: 8944415.

1995 - 1991

Gallagher, PJ; Garcia, JG; Herring, BP Expression of a novel myosin light chain kinase in embryonic tissues and cultured cells. J Biol Chem, 270(49), 29090-5. 1995.
PMID: 7493932.
PMCID: PMC2836784.
Garcia, JG; Schaphorst, KL Regulation of endothelial cell gap formation and paracellular permeability. J Investig Med, 43(2), 117-26. 1995.
PMID: 7735915.
Garcia, JG; Cruz, MD; Rollan, CM; Perez, CP; Alonso, AG Superoxide dismutase (SOD) and neutrophil infiltration in intestinal ischaemia-revascularization. Int Surg, 80(1), 95-7. 1995.
PMID: 7657505
Garcia, JG; Pavalko, FM; Patterson, CE Vascular endothelial cell activation and permeability responses to thrombin. Blood Coagul Fibrinolysis, 6(7), 609-26. 1995.
PMID: 8562832.
Patterson, CE; Stasek, JE; Schaphorst, KL; Davis, HW; Garcia, JG Mechanisms of pertussis toxin-induced barrier dysfunction in bovine pulmonary artery endothelial cell monolayers. Am J Physiol, 268(6 Pt 1), L926-34. 1995.
PMID: 7541950.
Siddiqui, RA; English, D; Harvey, K; Cui, Y; Martin, MI; Wentland, J; Akard, L; Jansen, J; Thompson, J; Garcia, JG Phorbol ester-induced priming of superoxide generation by phosphatidic acid-stimulated neutrophils and granule-free neutrophil cytoplasts. J Leukoc Biol, 58(2), 189-95. 1995.
PMID: 7643013.
Siddiqui, R; English, D; Garcia, JG Rationale for juxtacrine regulation of neutrophil interactions with the stimulated endothelium. J Lab Clin Med, 125(1), 18-25. 1995.
PMID: 7822943
Spain, BA; Cummings, O; Garcia, JG Bronchiolitis obliterans in an animal feed worker. Am J Ind Med, 28(3), 437-43. 1995.
PMID: 7485196
Natarajan, V; Jayaram, HN; Scribner, WM; Garcia, JG Activation of endothelial cell phospholipase D by sphingosine and sphingosine-1-phosphate. Am J Respir Cell Mol Biol, 11(2), 221-9. 1994.
PMID: 8049083.
Patterson, CE; Davis, HW; Schaphorst, KL; Garcia, JG Mechanisms of cholera toxin prevention of thrombin- and PMA-induced endothelial cell barrier dysfunction. Microvasc Res, 48(2), 212-35. 1994.
PMID: 7854206.
Patterson, CE; Garcia, JG Regulation of thrombin-induced endothelial cell activation by bacterial toxins. Blood Coagul Fibrinolysis, 5(1), 63-72. 1994.
PMID: 8180340.
al-Hassani, MH; Garcia, JG; Gunst, SJ Differences in Ca2+ mobilization by muscarinic agonists in tracheal smooth muscle. Am J Physiol, 264(1 Pt 1), L53-9. 1993.
PMID: 8430815.
Beckman, TA; Garcia, JG; Mastrangelo, M; Taylor, CR Physician volunteers 'give back to community'. Interview by Tina Sims. Indiana Med, 86(3), 226-7. 1993.
PMID: 8515041
Dodson, RF; O'Sullivan, M; Corn, CJ; Garcia, JG; Stocks, JM; Griffith, DE Analysis of ferruginous bodies in bronchoalveolar lavage from foundry workers. Br J Ind Med, 50(11), 1032-8. 1993.
PMID: 8280628
PMCID: PMC1035538.
Griffith, DE; Garcia, JG; Dodson, RF; Levin, JL; Kronenberg, RS Airflow obstruction in nonsmoking, asbestos- and mixed dust-exposed workers. Lung, 171(4), 213-24. 1993.
PMID: 8341088
Natarajan, V; Taher, MM; Roehm, B; Parinandi, NL; Schmid, HH; Kiss, Z; Garcia, JG Activation of endothelial cell phospholipase D by hydrogen peroxide and fatty acid hydroperoxide. J Biol Chem, 268(2), 930-7. 1993.
PMID: 8419372.
Parkinson, JF; Bang, NU; Garcia, JG Recombinant human thrombomodulin attenuates human endothelial cell activation by human thrombin. Arterioscler Thromb, 13(7), 1119-23. 1993.
PMID: 8391310.
Stasek, JE; Natarajan, V; Garcia, JG Phosphatidic acid directly activates endothelial cell protein kinase C. Biochem Biophys Res Commun, 191(1), 134-41. 1993.
PMID: 8447819.
English, D; Akard, LP; Taylor, GS; Rizzo, MT; Dominguez, J; Garcia, JG Gp-regulated phosphoinositide hydrolysis in turkey and human erythrocytes exposed to fluoride ion: relationship to calcium influx. J Lab Clin Med, 119(1), 87-98. 1992.
PMID: 1309378.
Garcia, JG; Stasek, J; Natarajan, V; Patterson, CE; Dominguez, J Role of protein kinase C in the regulation of prostaglandin synthesis in human endothelium. Am J Respir Cell Mol Biol, 6(3), 315-25. 1992.
PMID: 1540395.
Griffith, DE; Garcia, JG; James, HL; Callahan, KS; Iriana, S; Holiday, D Hyperoxic exposure in humans. Effects of 50 percent oxygen on alveolar macrophage leukotriene B4 synthesis. Chest, 101(2), 392-7. 1992.
PMID: 1310457
Harrington, MA; Daub, R; Song, A; Stasek, J; Garcia, JG Interleukin 1 alpha mediated inhibition of myogenic terminal differentiation: increased sensitivity of Ha-ras transformed cultures. Cell Growth Differ, 3(4), 241-8. 1992.
PMID: 1325182.
Sacks, DB; Davis, HW; Williams, JP; Sheehan, EL; Garcia, JG; McDonald, JM Phosphorylation by casein kinase II alters the biological activity of calmodulin. Biochem J, 283 ( Pt 1) 21-4. 1992.
PMID: 1314563.
PMCID: PMC1130984.
Dodson, RF; Garcia, JG; O'Sullivan, M; Corn, C; Levin, JL; Griffith, DE; Kronenberg, RS The usefulness of bronchoalveolar lavage in identifying past occupational exposure to asbestos: a light and electron microscopy study. Am J Ind Med, 19(5), 619-28. 1991.
PMID: 1647134
Dominguez, JH; Garcia, JG; Rothrock, JK; English, D; Mann, C Fluoride mobilizes intracellular calcium and promotes Ca2+ influx in rat proximal tubules. Am J Physiol, 261(2 Pt 2), F318-27. 1991.
PMID: 1652206.
Kronenberg, RS; Levin, JL; Dodson, RF; Garcia, JG; Griffith, DE Asbestos-related disease in employees of a steel mill and a glass bottle manufacturing plant. Toxicol Ind Health, 7(1-2), 73-9. 1991.
PMID: 1853355
Kronenberg, RS; Levin, JL; Dodson, RF; Garcia, JG; Griffith, DE Asbestos-related disease in employees of a steel mill and a glass bottle-manufacturing plant. Ann N Y Acad Sci, 643 397-403. 1991.
PMID: 1809151

1990 - 1984

Callahan, KS; Griffith, DE; Garcia, JG Asbestos exposure results in increased lung procoagulant activity in vivo and in vitro. Chest, 98(1), 112-9. 1990.
PMID: 2361375.
Garcia, JG; Griffith, DE; Williams, JS; Blevins, WJ; Kronenberg, RS Reduced diffusing capacity as an isolated finding in asbestos- and silica-exposed workers. Chest, 98(1), 105-11. 1990.
PMID: 2163299.
Rizzo, MT; Tricot, G; Hoffman, R; Jayaram, HN; Weber, G; Garcia, JG; English, D Inosine monophosphate dehydrogenase inhibitors. Probes for investigations of the functions of guanine nucleotide binding proteins in intact cells. Cell Signal, 2(6), 509-19. 1990.
PMID: 1981974.
Taylor, GS; Garcia, JG; Dukes, R; English, D High-performance liquid chromatographic analysis of radiolabeled inositol phosphates. Anal Biochem, 188(1), 118-22. 1990.
PMID: 2221351.
Garcia, JG; Griffith, DE; Cohen, AB; Callahan, KS Alveolar macrophages from patients with asbestos exposure release increased levels of leukotriene B4. Am Rev Respir Dis, 139(6), 1494-501. 1989.
PMID: 2543249.
Stocks, JM; Wallace, RJ; Griffith, DE; Garcia, JG; Kohler, RB Ofloxacin in community-acquired lower respiratory infections. A comparison with amoxicillin or erythromycin. Am J Med, 87(6C), 52S-56S. 1989.
PMID: 2690620
Garcia, JG; Azghani, A; Callahan, KS; Johnson, AR Effect of platelet activating factor on leukocyte-endothelial cell interactions. Thromb Res, 51(1), 83-96. 1988.
PMID: 2842887.
Garcia, JG; Perlman, MB; Ferro, TJ; Johnson, A; Jubiz, W; Malik, AB Inflammatory events after fibrin microembolization. Alterations in alveolar macrophage and neutrophil function. Am Rev Respir Dis, 137(3), 630-5. 1988.
PMID: 2830812.
Griffith, DE; Garcia, JG Asthmatic bronchitis. Semin Respir Infect, 3(1), 27-39. 1988.
PMID: 3283880
Selig, WM; Burhop, KE; Garcia, JG; Malik, AB Substance P-induced pulmonary vasoreactivity in isolated perfused guinea pig lung. Circ Res, 62(2), 196-203. 1988.
PMID: 2448056.
Wallace, RJ; Steele, LC; Brooks, DL; Forrester, GD; Garcia, JG; Luman, JI; Wilson, RW; Shepherd, S; McLarty, J Ampicillin, tetracycline, and chloramphenicol resistant Haemophilus influenzae in adults with chronic lung disease. Relationship of resistance to prior antimicrobial therapy. Am Rev Respir Dis, 137(3), 695-9. 1988.
PMID: 3257853.
Cooper, JA; Del Vecchio, PJ; Minnear, FL; Burhop, KE; Selig, WM; Garcia, JG; Malik, AB Measurement of albumin permeability across endothelial monolayers in vitro. J Appl Physiol (1985), 62(3), 1076-83. 1987.
PMID: 3571065.
Garcia, JG; Munim, A; Nugent, KM; Bishop, M; Hoie-Garcia, P; Parhami, N; Keogh, BA Alveolar macrophage gold retention in rheumatoid arthritis. J Rheumatol, 14(3), 435-8. 1987.
PMID: 3114483
Garcia, JG; Noonan, TC; Jubiz, W; Malik, AB Leukotrienes and the pulmonary microcirculation. Am Rev Respir Dis, 136(1), 161-9. 1987.
PMID: 3037955.
Idell, S; Gonzalez, K; Bradford, H; MacArthur, CK; Fein, AM; Maunder, RJ; Garcia, JG; Griffith, DE; Weiland, J; Martin, TR Procoagulant activity in bronchoalveolar lavage in the adult respiratory distress syndrome. Contribution of tissue factor associated with factor VII. Am Rev Respir Dis, 136(6), 1466-74. 1987.
PMID: 3688650.
Weiland, JE; Garcia, JG; Davis, WB; Gadek, JE Neutrophil collagenase in rheumatoid interstitial lung disease. J Appl Physiol (1985), 62(2), 628-33. 1987.
PMID: 3031003
Burhop, KE; Garcia, JG; Selig, WM; Lo, SK; van der Zee, H; Kaplan, JE; Malik, AB Platelet-activating factor increases lung vascular permeability to protein. J Appl Physiol (1985), 61(6), 2210-7. 1986.
PMID: 3804927.
Garcia, JG; Parhami, N; Killam, D; Garcia, PL; Keogh, BA Bronchoalveolar lavage fluid evaluation in rheumatoid arthritis. Am Rev Respir Dis, 133(3), 450-4. 1986.
PMID: 3485395
Garcia, JG; Siflinger-Birnboim, A; Bizios, R; Del Vecchio, PJ; Fenton, JW; Malik, AB Thrombin-induced increase in albumin permeability across the endothelium. J Cell Physiol, 128(1), 96-104. 1986.
PMID: 3722274.
Malik, AB; Noonan, TC; Selig, WM; Garcia, JG Effects of exogeneous leukotrienes on the pulmonary circulation. Prog Clin Biol Res, 199 221-35. 1985.
PMID: 2999824
Garcia, JG; Keogh, BA Bronchoalveolar lavage: a decade later. Ir Med J, 77(12), 399-401. 1984.
PMID: 6394542