Shear-mediated platelet activation in the free flow: Perspectives on the emerging spectrum of cell mechanobiological mechanisms mediating cardiovascular implant thrombosis.

TitleShear-mediated platelet activation in the free flow: Perspectives on the emerging spectrum of cell mechanobiological mechanisms mediating cardiovascular implant thrombosis.
Publication TypeJournal Article
Year of Publication2017
AuthorsSlepian MJ, Sheriff J, Hutchinson M, Tran P, Bajaj N, Garcia JGN, S Saavedra S, Bluestein D
JournalJ Biomech
Volume50
Pagination20-25
Date Published2017 Jan 04
ISSN Number1873-2380
KeywordsBlood Platelets, Humans, Platelet Activation, Prostheses and Implants, Stress, Mechanical, Thrombosis
Abstract

<p>Shear-mediated platelet activation (SMPA) is central in thrombosis of implantable cardiovascular therapeutic devices. Despite the morbidity and mortality associated with thrombosis of these devices, our understanding of mechanisms operative in SMPA, particularly in free flowing blood, remains limited. Herein we present and discuss a range of emerging mechanisms for consideration for "free flow" activation under supraphysiologic shear. Further definition and manipulation of these mechanisms will afford opportunities for novel pharmacologic and mechanical strategies to limit SMPA and enhance overall implant device safety.</p>

DOI10.1016/j.jbiomech.2016.11.016
Alternate JournalJ Biomech
PubMed ID27887727
PubMed Central IDPMC5309211
Grant ListR01 EB008004 / EB / NIBIB NIH HHS / United States
R21 HL096930 / HL / NHLBI NIH HHS / United States
U01 EB012487 / EB / NIBIB NIH HHS / United States
U01 HL131052 / HL / NHLBI NIH HHS / United States