Steven M. Dudek, MD
1990 BA Behavioral Biology, Johns Hopkins University, Baltimore, MD
1995 MD Washington University, St. Louis, MO
1995-1998 Internship/ Residency Internal Medicine, Johns Hopkins University, Baltimore, MD
1998-2002 Fellowship Pulmonary & Critical Care, John Hopkins University, Baltimore, MD
Clinical Research and Interests:
Dr. Dudek’s research seeks to mechanistically characterize the regulation of pulmonary vascular barrier function, with a particular emphasis on in vitro and animal models of acute lung injury syndromes. His recent work has focused on endothelial cell cytoskeletal rearrangements involved in regulating pulmonary vascular leak as well as identifying novel agents for reversing this pathophysiological process.
Dessap AM, Voiriot G, Zhou T, Marcos E, Dudek SM, Jacobson JR, Machado R, Adnot S, Brochard L, Maitre B, Garcia JGN. Conflicting physiological and genomic cardiopulmonary effects of recruitment maneuvers in murine acute lung injury. Am J Respir Cell Mol Biol, 46(4):541-50, 2012.
Muñoz NM, Desai A, Meliton LN, Meliton AY, Zhou T, Leff AR, Dudek SM. Group V phospholipase A2 increases pulmonary endothelial permeability through direct hydrolysis of the cell membrane. Pulm Circ, 2(2):182-92, 2012.
Sun X, Singleton PA, Letsiou E, Zhao J, Belvitch P, Sammani S, Chiang ET, Moreno- Vinasco L, Wade MS, Zhou T, Liu B, Parastatidis I, Thomson L, Ischiropoulos H, Natarajan V, Jacobson JR, Machado RF, Dudek SM, Garcia JGN. Sphingosine-1- phosphate receptor 3 is a novel biomarker in acute lung injury. Am J Respir Cell Mol Biol, 47:628-36, 2012.
Epshtein Y, Singleton P, Chen W, Wang L, Salgia R, Kanteti P, Dudek SM, Garcia JG, Jacobson JR. Critical role of S1PR1 and Integrin β4 in HGF/c-Met-mediated increases in vascular integrity. J Biol Chem, 288(4):2191-200, 2013.
Mathew B, Jacobson JR, Siegler JH, Moitra J, Blasco M, Xie L, Unzueta C, Zhou T, Evenoski C, Al-Sakka M, Sharma R, Huey B, Bulent A, Smith B, Sundararajan J, Reddy NM, Reddy SP, Fingerle-Rowson G, Bucala R, Dudek SM, Natarajan V, Weichselbaum RR, Garcia JGN. Role of MIF in age-related susceptibility to radiation lung injury via Nrf2 and antioxidant regulation. Am J Respir Cell Mol Biol, in press.
Arce FT, Meckes B, Camp SM, Garcia JGN, Dudek SM*, Lal R*. Heterogeneous elastic response of human lung microvascular endothelial cells to barrier modulating stimuli. Nanomedicine, in press. *co-senior authors
Adyshev DM, Dudek SM, Moldobaeva NK, Kim K, Ma SF, Kasa A, Garcia JGN, Verin AD. Ezrin/radixin/moesin proteins differentially regulate endothelial hyperpermeability after thrombin. Am J Physiol Lung Cell Mol Physiol, in press.